{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:05:06Z","timestamp":1794024306467,"version":"4.8.0"},"reference-count":107,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mobility and rehabilitation for patients supported on extracorporeal life support (ECLS) are high-risk and resource-intensive endeavors that currently lack a standardized framework to guide comprehensive program development. This paper introduces the framework to serve as a structured model that integrates best practice recommendations, relevant literature, and practical data from an ELSO Gold Level Center of Excellence program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Initially developed in response to the COVID-19 pandemic, the ECMO mobility program matured into a proactive and sustainable system through multidisciplinary collaboration, incorporation of current evidence, and iterative reflective practice. The resulting framework offers a structured, holistic approach to establishing effective ECLS mobility program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Mobility Under the Support of ECLS (\u201cMUSECLS\u201d) framework comprised five interconnected domains, beginning with patient and family engagement and extending to institutional values and infrastructure. Implementation strategies and programmatic data from the originating ECMO center are used to illustrate practical application of the framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The MUSECLS framework provides a scalable and adaptable model to support the development or refinement of ECMO mobility and rehabilitation programs. It allows centers to tailor practices to local resources and populations while ensuring a comprehensive, evidence-informed approach. The framework is designed to remain applicable as clinical care and research in ECLS continue to advance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591251394851","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T16:34:17Z","timestamp":1762792457000},"page":"672-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and application of a novel framework for mobility &amp; rehabilitation under support of extracorporeal life support: The MUSECLS framework"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-0594","authenticated-orcid":false,"given":"Aaron H.","family":"Thrush","sequence":"first","affiliation":[{"name":"Cleveland Clinic Abu Dhabi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Tylor","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Ghisulal","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-3283","authenticated-orcid":false,"given":"Vivek","family":"Kakar","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001783"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00248-X"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2020.102829"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzab301"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1271540"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591221096078"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002375"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591221133657"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002702"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000001095"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14110"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pri.1950"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003482"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000001001"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/wvn.12290"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/2455-5568.196870"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2012-000952"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/pq9.0000000000000126"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2023-002669"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzab154"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2018.1448469"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/CPT.0000000000000277"},{"key":"e_1_3_6_24_2","unstructured":"National Health Service. Multi-professional framework for advanced clinical practice in England 2017. https:\/\/www.hee.nhs.uk\/sites\/default\/files\/documents\/multi-professionalframeworkforadvancedclinicalpracticeinengland.pdf (accessed 1 May 2025)."},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzy095"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.789828"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzac044"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/QMH.0000000000000289"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2021.08.009"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026348"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2023.104465"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2023.2266993"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2022.05.008"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00776-3"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.08.03"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2023.05.022"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.10.048"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002822"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227248"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-021-01210-4"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.03.151"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.849"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-017-1004-3"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14604"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002770"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002179"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjtc.2022.01.026"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.17079"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2022.00031"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003299"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03741-z"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.01.002"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.08.002"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9020034"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14446"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002154"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201606-484OC"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.4037\/aacnacc2022293"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2025452"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/1751143717705801"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-01075-z"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2021689"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000239"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1097\/JAT.0000000000000247"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/CNQ.0000000000000206"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4908-8"},{"issue":"4","key":"e_1_3_6_67_2","first-page":"e0090","article-title":"Early mobilization in the ICU: a collaborative, integrated approach","volume":"2","author":"Linke CA","year":"2020","unstructured":"Linke CA, Chapman LB, Berger LJ, et al. Early mobilization in the ICU: a collaborative, integrated approach. Crit Care Explor 2020; 2(4): e0090.","journal-title":"Crit Care Explor"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.64517\/DOSQ8471"},{"key":"e_1_3_6_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2023.154447"},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-024-10701-6"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.05.001"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320917795"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.11132"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2467"},{"key":"e_1_3_6_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10591"},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.11.036"},{"key":"e_1_3_6_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5319-1"},{"key":"e_1_3_6_78_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.17714"},{"key":"e_1_3_6_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzab024"},{"key":"e_1_3_6_80_2","first-page":"A1643","article-title":"Functional electrical stimulation cycling Pre- and post-bilateral orthotopic lung transplantation: a case report","volume":"191","author":"Pastva A","year":"2015","unstructured":"Pastva A, Kirk T, Parry SM. Functional electrical stimulation cycling Pre- and post-bilateral orthotopic lung transplantation: a case report. Am J Respir Crit Care Med 2015; 191: A1643.","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_6_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.03.007"},{"key":"e_1_3_6_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2020.05.010"},{"key":"e_1_3_6_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001557"},{"key":"e_1_3_6_84_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526924816640646"},{"key":"e_1_3_6_85_2","unstructured":"Ramsey S Purrington B Slay D. Intubated. Cannulated. Ambulated: management of complex patients on ECMO. In: Education session presented at: Combined Sections Meeting 2025 Feb 14."},{"key":"e_1_3_6_86_2","volume-title":"AIUM Online Learning Center","author":"Ramsey S","year":"2023","unstructured":"Ramsey S. POCUS in PT: an introduction to cardiovascular and pulmonary diagnostics ultrasound, Part 1. In: AIUM Online Learning Center, 2023. https:\/\/learn.aium.org\/products\/pocus-in-pt-an-introduction-to-cardiovascular-and-pulmonary-diagnostic-ultrasound-part-1#tab-product_tab_cme_information (accessed 1 May 2025)."},{"key":"e_1_3_6_87_2","doi-asserted-by":"publisher","DOI":"10.24908\/pocus.v9i2.17854"},{"key":"e_1_3_6_88_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000331"},{"key":"e_1_3_6_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.07.001"},{"key":"e_1_3_6_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz042"},{"key":"e_1_3_6_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2021.05.002"},{"key":"e_1_3_6_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.08.010"},{"key":"e_1_3_6_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2017.06.005"},{"key":"e_1_3_6_94_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-5153.2010.00398.x"},{"key":"e_1_3_6_95_2","doi-asserted-by":"publisher","DOI":"10.1097\/NCQ.0000000000000263"},{"key":"e_1_3_6_96_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20120336"},{"key":"e_1_3_6_97_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1005162"},{"key":"e_1_3_6_98_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.19.13287-7"},{"key":"e_1_3_6_99_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2019.00064"},{"key":"e_1_3_6_100_2","doi-asserted-by":"publisher","DOI":"10.1017\/cts.2021.789"},{"key":"e_1_3_6_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/lrh2.10328"},{"issue":"10","key":"e_1_3_6_102_2","first-page":"526","article-title":"A practical tool to identify and eliminate barriers to compliance with evidence-based guidelines","volume":"35","author":"Gurses AP","year":"2009","unstructured":"Gurses AP, Murphy DJ, Martinez EA, et al. A practical tool to identify and eliminate barriers to compliance with evidence-based guidelines. Jt Comm J Qual Patient Saf 2009; 35(10): 526\u2013585.","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"e_1_3_6_103_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-071188"},{"key":"e_1_3_6_104_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.06.003"},{"key":"e_1_3_6_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suw016"},{"key":"e_1_3_6_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2022.07.003"},{"key":"e_1_3_6_107_2","unstructured":"Alfred T. Mobilisation & Physiotherapy 2025. https:\/\/ecmo.icu\/daily-care-organ-support-in-ecmo-mobilisation-physiotherapy (accessed 1 Dec 2024)."},{"key":"e_1_3_6_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2024.103750"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591251394851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591251394851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591251394851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:30:39Z","timestamp":1783341039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591251394851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":107,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/02676591251394851"],"URL":"https:\/\/doi.org\/10.1177\/02676591251394851","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}