{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:29:09Z","timestamp":1793971749642,"version":"4.8.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bioprosthetic heart valves (BHVs) are increasingly used in valvular heart disease, offering favourable haemodynamics and lower thrombogenic risk compared to mechanical valves. However, long-term durability remains limited by structural valve degeneration (SVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 70-year-old male presented with severe heart failure 4\u00a0years after bioprosthetic mitral and aortic valve replacement. Imaging confirmed SVD affecting both valves, necessitating high-risk redo surgery. Postoperatively, the patient developed profound systemic inflammatory response syndrome (SIRS) to cardiopulmonary bypass (CPB), refractory to vasopressors and steroids, and died within 24\u00a0hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Further investigations revealed elevated isolated anti-cardiolipin IgM antibodies, raising suspicion of autoimmune-mediated valve thrombosis as a contributor to this case of early SVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of thorough diagnostic evaluation in cases of early SVD, the need to individualise anticoagulation strategies in at-risk patients, and serves as a critical reminder of the serious inflammatory complications that can occur post-surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591251413476","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:23:29Z","timestamp":1766575409000},"page":"1573-1576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Autoimmune-associated early double bioprosthetic valve failure: A case report"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8210-5673","authenticated-orcid":false,"given":"Sarah","family":"Guo","sequence":"first","affiliation":[{"name":"University Hospital Southampton"},{"name":"University of Cambridge School of Clinical Medicine"},{"name":"University of Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-3119","authenticated-orcid":false,"given":"Hazem","family":"Aljasem","sequence":"additional","affiliation":[{"name":"University Hospital Southampton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Ali-Ghosh","sequence":"additional","affiliation":[{"name":"University Hospital Southampton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Ohri","sequence":"additional","affiliation":[{"name":"University Hospital Southampton"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx141"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.08.015"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2003.12.013"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx244"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000372"},{"key":"e_1_3_7_7_2","doi-asserted-by":"crossref","unstructured":"Kostyunin AE Yuzhalin AE Rezvova MAet al. 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