{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:29:09Z","timestamp":1793971749621,"version":"4.8.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Extracorporeal membrane oxygenation (ECMO) involves the use of a synthetic circuit, which initiates a complex interplay of inflammatory and pro-coagulant responses. This intricate, self-reinforcing process results in a prothrombotic state, predisposing patients to arterial, venous, or oxygenator thrombosis. Unfractionated heparin is the standard anticoagulant chosen in ECMO patients to prevent such complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>In this case report our patient presented heparin-induced thrombocytopenia (HIT), a possible complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Alternative strategies such as bivalirudin and argatroban are possible options but due the unavailability of those medications at our institution, nitric oxide (NO) via sweep-gas flow was deemed a reasonable alternative considering it\u2019s anti-aggregant effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case report details the use of NO as a possible alternative anticoagulant strategy in a patient with ECMO complicated by HIT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261416014","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T13:33:37Z","timestamp":1769866417000},"page":"1565-1568","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nitric oxide in the ECMO circuit as a treatment option for heparin-induced thrombocytopenia: A case report"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-1334","authenticated-orcid":false,"given":"Daniel","family":"Joelsons","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-3535","authenticated-orcid":false,"given":"Leonardo Van de Wiel Barros Urbano","family":"Andari","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-8829","authenticated-orcid":false,"given":"Pedro Paulo","family":"Zanella do Amaral Campos","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Gomes","family":"M\u00f3l","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno de Arruda","family":"Bravim","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-6498","authenticated-orcid":false,"given":"Giles J","family":"Peek","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ECMO Team HIAE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/202254142"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-17572-5"},{"key":"e_1_3_6_4_2","volume-title":"Extracorporeal life support: the ELSO red book","author":"Maclaren G,","year":"2022","unstructured":"Maclaren G,, Lorusso R,, Brodie D, et al. Extracorporeal life support: the ELSO red book. 6. ed. [Sl]. Extracorporeal Life Support Organization, 2022."},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-021-01176-3"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-1387"},{"key":"e_1_3_6_7_2","volume-title":"StatPearls [Internet]","author":"Nicolas D","year":"2025","unstructured":"Nicolas D, Nicolas S, Hodgens A, et al. Heparin-Induced thrombocytopenia. In StatPearls [Internet]. StatPearls Publishing, 2025. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482330\/"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14608"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1999.00459.x"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0267659117720495"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002164"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261416014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591261416014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261416014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:55:47Z","timestamp":1793969747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591261416014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/02676591261416014"],"URL":"https:\/\/doi.org\/10.1177\/02676591261416014","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]}}}