{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:29Z","timestamp":1791614969829,"version":"4.3.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Due to anticoagulation during Extracorporeal Membrane Oxygenation (ECMO), patients face a higher risk of bleeding. This study aimed to assess the correlation between anticoagulation assays and hemorrhage in ECMO patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed records from patients in our critical care units, comparing anticoagulation parameters with clinical outcomes. Statistical analyses included the Wilcoxon rank sum test for continuous variables and chi-square or Fisher\u2019s exact tests for categorical variables. We used Kaplan-Meier curves to depict hemorrhage incidence and logistic regression to identify factors associated with bleeding and mortality. Linear regression assessed coagulation factors linked to length of stay (LOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 76 patients, 32 (42.1%) experienced hemorrhage; 15 (46.9%) of these survived. Survivors had a higher proportion without bleeding (68.2%). Hemorrhage patients had more circuit changes (18.8% vs 2.3%, p = .01). The 10-, 20-, and 30-days cumulative hemorrhage incidences were 36.9%, 58.8%, and 72.5%, respectively. Multivariable analysis suggested that bleeding patients had a higher aPTT prior to the bleeding event compared with the median aPTT in non-bleeding patients (p = 0.04), and ACT and PT levels showed a trend towards a significant association (p = 0.06). Longer ECMO runs and circuit changes increased hemorrhage risk (OR = 1.004 and OR = 12.85, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study found that higher aPTT and longer ECMO duration are independent hemorrhage risk factors, underscoring the need for timely ECMO decannulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261417542","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:46:24Z","timestamp":1768319184000},"page":"1260-1270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of anticoagulation assays with bleeding during extracorporeal membrane oxygenation at a tertiary pediatric hospital"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-2062","authenticated-orcid":false,"given":"Mohammed","family":"Salameh","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazmin","family":"Delgado","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine at CHIRSTUS Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Killebrew","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Henderson","sequence":"additional","affiliation":[{"name":"CHRISTUS Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elumalai","family":"Appachi","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine at CHIRSTUS Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000002128"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1570-4"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000603"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.76.4.479"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001438"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.06.005"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001652"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182904a52"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003215"},{"key":"e_1_3_5_11_2","volume-title":"Stata 18 lasso reference manual","author":"StataCorp","year":"2023","unstructured":"StataCorp. 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