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Preventing and treating pulmonary complications has become a critical clinical issue. Optimizing ventilation strategies during the preoperative, intraoperative, and postoperative stages is essential for adequate lung protection and preventing CPB-related pulmonary injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of multiple databases including PubMed, Embase, and the Cochrane Library was conducted. After removing the duplicate studies, full-text review was performed, and all studies that reported mechanical ventilation strategies and lung protection during CPB were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review systematically examines ventilation strategies during CPB, outlining optimized parameters and pharmacologic approaches across pre-, intra-, and post-CPB phases to reduce lung injury. Various modes \u2014 including volume control ventilation (VCV), pressure control ventilation (PCV), and pressure-controlled ventilation\u2013volume guaranteed (PCV-VG) \u2014 demonstrate unique benefits and limitations. When combined with protective measures (low tidal volume [LTV], moderate positive end-expiratory pressure [PEEP], and recruitment maneuvers), they show clinical efficacy in lung protection. Pharmacologic agents like ambroxol, neutrophil elastase inhibitors, and sivelestat further enhance protection, underscoring the promise of combined mechanical-pharmacological strategies against CPB-induced lung injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A comprehensive approach integrating individualized ventilation management and pharmacological intervention is key to reducing CPB-induced lung injury, enhancing postoperative respiratory function, and improving patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261423003","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:06:29Z","timestamp":1770062789000},"page":"1114-1124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanical ventilation strategies and lung protection during cardiopulmonary bypass: A scoping review"],"prefix":"10.1177","volume":"41","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[{"name":"Lanzhou University"},{"name":"Lanzhou University"},{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Lu","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhan","family":"Huang","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-8875","authenticated-orcid":false,"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University"},{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_3_6_2_2","volume-title":"StatPearls","author":"Ismail A","year":"2025","unstructured":"Ismail A, Semien G, Sharma S, et al. 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