{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:58:43Z","timestamp":1791550723679,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Myocardial protection research in adult cardiac surgery has increasingly examined single dose del Nido cardioplegia alongside conventional multidose blood cardioplegia. Using a scientometric modeling approach, this study aims to quantitatively evaluate whether the thematic emphasis of this literature has expanded over time from pure protection efficacy toward workflow-related procedural parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 269 focal publications published between 2000 and 2025, representing a 25-years analytical period, comparing myocardial protection strategies were analyzed using the Web of Science (WoS) Core Collection database. Author keywords were stratified by two independent reviewers into two predefined conceptual domains: the Efficacy Domain, including terms related to physiological myocardial protection (e.g., troponin, ischemia-reperfusion), and the Efficiency Domain, including workflow-related procedural parameters (e.g., cross-clamp time, minimally invasive surgery, single dose cardioplegia), with strong inter-rater agreement (Cohen\u2019s \u03ba = 0.92). Temporal trends were quantified using weighted linear regression models to evaluate the association between publication year and the relative prominence of efficiency-domain terminology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of publication volume reveals a marked increase in literature, particularly from 2018 onwards. Keyword network analysis identified three distinct clusters: (1) traditional blood cardioplegia, (2) modern adult surgery\/minimally invasive applications, and (3) evidence synthesis. Trend analysis demonstrated a statistically significant increase in the prominence of efficiency-related terms over the study period (\u03b2 = 0.027 per year, 95% CI 0.014\u20130.040;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for trend &lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This scientometric analysis indicates an increasing emphasis in the literature on workflow-related procedural parameters in the evaluation of cardioplegia strategies in adult cardiac surgery. Contemporary studies increasingly report workflow-related procedural parameters such as uninterrupted surgical flow, cross-clamp time, and compatibility with minimally invasive or robotic techniques in the evaluation of cardioplegia strategies. These findings indicate an expanding investigational emphasis within the literature toward workflow-related procedural parameters alongside traditional efficacy and safety-oriented outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261439568","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:51:26Z","timestamp":1774561886000},"page":"751-757","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evolution of myocardial protection strategies: The rise of del Nido cardioplegia in adult cardiac surgery"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-7124","authenticated-orcid":false,"given":"Bedirhan Bu\u011fra","family":"Bay\u0131c\u0131","sequence":"first","affiliation":[{"name":"Ko\u015fuyolu High Specialization Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-371X","authenticated-orcid":false,"given":"Fatih","family":"K\u0131z\u0131lyel","sequence":"additional","affiliation":[{"name":"Ko\u015fuyolu High Specialization Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"issue":"2","key":"e_1_3_5_2_2","first-page":"98","article-title":"Myocardial protection: an overview","volume":"5","author":"Buckberg GD","year":"1993","unstructured":"Buckberg GD. Myocardial protection: an overview. Semin Thorac Cardiovasc Surg 1993; 5(2): 98\u2013106.","journal-title":"Semin Thorac Cardiovasc Surg"},{"issue":"1","key":"e_1_3_5_3_2","first-page":"52","article-title":"History and use of del Nido cardioplegia solution at Boston Children's Hospital","volume":"144","author":"Matte GS","year":"2012","unstructured":"Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children's Hospital. J Thorac Cardiovasc Surg 2012; 144(1): 52\u2013103.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"e_1_3_5_4_2","first-page":"124","article-title":"Single dose myocardial protection with del Nido cardioplegia during adult cardiac surgery","volume":"143","author":"Charette K","year":"2012","unstructured":"Charette K, Gerrah R, Quaegebeur J, et al. Single dose myocardial protection with del Nido cardioplegia during adult cardiac surgery. J Thorac Cardiovasc Surg 2012; 143(1): 124\u2013130.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.085"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.09.146"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-020-1082-9"},{"issue":"8","key":"e_1_3_5_8_2","first-page":"794","article-title":"Del Nido cardioplegia in adult cardiac surgery: the new kid on the block","volume":"25","author":"Misra S","year":"2016","unstructured":"Misra S, Srinivasan A, Jena SS, et al. Del Nido cardioplegia in adult cardiac surgery: the new kid on the block. Heart Lung Circ 2016; 25(8): 794\u2013800.","journal-title":"Heart Lung Circ"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-009-0146-3"},{"issue":"4","key":"e_1_3_5_10_2","first-page":"874","article-title":"Safety and efficacy of del Nido cardioplegia in adult cardiac surgery","volume":"150","author":"Ramanathan R","year":"2015","unstructured":"Ramanathan R, Parrish DW, Hammon JW, et al. Safety and efficacy of del Nido cardioplegia in adult cardiac surgery. J Thorac Cardiovasc Surg 2015; 150(4): 874\u2013879.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_3_5_11_2","first-page":"114","article-title":"Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting","volume":"16","author":"Yammine M","year":"2014","unstructured":"Yammine M, Nezafati P, Nento DE, et al. Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting. J Cardiothorac Surg 2014; 16: 114.","journal-title":"J Cardiothorac Surg"},{"issue":"3","key":"e_1_3_5_12_2","first-page":"817","article-title":"Comparison of del Nido and St Thomas cardioplegia solutions in adult aortic valve surgery","volume":"104","author":"Vistarini N","year":"2017","unstructured":"Vistarini N, Lalibert\u00e9 E, Beauchamp P, et al. Comparison of del Nido and St Thomas cardioplegia solutions in adult aortic valve surgery. Ann Thorac Surg 2017; 104(3): 817\u2013823.","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"e_1_3_5_13_2","first-page":"165","article-title":"The use of del Nido cardioplegia in adult valve surgery","volume":"29","author":"O'Brien J","year":"2014","unstructured":"O'Brien J, Akverdi I, Howlett SE, et al. The use of del Nido cardioplegia in adult valve surgery. J Card Surg 2014; 29(2): 165.","journal-title":"J Card Surg"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-014-0141-5"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0021-9509.17.09864-0"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12360"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.02.067"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.052"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.06.004"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.12.058"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261439568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591261439568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261439568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:30:12Z","timestamp":1783341012000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591261439568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/02676591261439568"],"URL":"https:\/\/doi.org\/10.1177\/02676591261439568","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]}}}