{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:01:36Z","timestamp":1784998896431,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"TKI-HTSM Medtech"},{"name":"Sorin Group Italy S.r.l."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"abstract":"<jats:p>\n                    This study aims to assess current quality indicators and determine the added value of total area under the threshold (TAUT) and largest area under the threshold (LAUT) for risk factors associated with post-cardiosurgical acute kidney injury (AKI) in a large patient population. This approach may offer insights to further reduce the incidence of AKI. Methods: This is a retrospective single center study of procedures from January 1st 2019 to August 31st 2023. The final cohort included 3086 patients who underwent on-pump cardiothoracic surgery procedures at a temperature \u2265 34\u00b0C. This study particularly focused of three risk factors for AKI, namely, the oxygen delivery (DO\n                    <jats:sub>2<\/jats:sub>\n                    i), venous saturation (SvO\n                    <jats:sub>2<\/jats:sub>\n                    ) and mean arterial pressure (MAP). Results: The TAUT-DO\n                    <jats:sub>2<\/jats:sub>\n                    i\n                    <jats:sup>300<\/jats:sup>\n                    (threshold value 300\u00a0mL\/min\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), as well as the TAUT-SvO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>70<\/jats:sup>\n                    (threshold value 70%) were significantly larger in the group of patients who developed AKI (P &lt; 0.001). The TAUT-MAP\n                    <jats:sup>60<\/jats:sup>\n                    (threshold value 60 mmHg) was significantly different between AKI and non-AKI groups during CPB, but they were significantly larger for the AKI group during the first 6 h at the ICU (P &lt; 0.001). Conclusion: The findings indicate that increased cumulative AUT-DO\n                    <jats:sub>2<\/jats:sub>\n                    i\n                    <jats:sup>300<\/jats:sup>\n                    exposure may be linked to a higher risk of AKI, supporting the potential role of AUT-based monitoring in guiding intraoperative management during on-pump cardiac surgery.\n                  <\/jats:p>","DOI":"10.1177\/02676591261471110","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:46:37Z","timestamp":1784785597000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovative use of quality indicators during cardiopulmonary bypass: a goal directed perfusion strategy using real-time area under the threshold analysis"],"prefix":"10.1177","author":[{"given":"Marloes","family":"van Hoeven","sequence":"first","affiliation":[{"name":"Catharina Hospital"},{"name":"Technical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gensen","sequence":"additional","affiliation":[{"name":"Catharina Hospital"},{"name":"Medical Spectrum Twente"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Overdevest","sequence":"additional","affiliation":[{"name":"Catharina Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"Gerritse","sequence":"additional","affiliation":[{"name":"Catharina Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Turco","sequence":"additional","affiliation":[{"name":"Technical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Bouwman","sequence":"additional","affiliation":[{"name":"Technical University"},{"name":"Catharina Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1191\/0267659102pf610oa"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"Velho TR Pereira RM Guerra NC et al. Low mean arterial pressure during cardiopulmonary bypass and the risk of acute kidney injury: a propensity score matched observational study. In: In seminars in cardiothoracic and vascular anesthesia 2021. Sage Publications.","DOI":"10.1177\/10892532211045765"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.07.078"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318210f86a"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0267659118766437"},{"issue":"2","key":"e_1_3_3_7_2","first-page":"ivaf002","article-title":"2024 EACTS\/EACTA\/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery","volume":"40","author":"Wahba A","year":"2025","unstructured":"Wahba A, Kunst G, De Somer F, et al. 2024 EACTS\/EACTA\/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery. Interdiscip. Cardiovasc. Thorac. Surg 2025; 40(2): ivaf002.","journal-title":"Interdiscip. Cardiovasc. Thorac. 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