{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:32:23Z","timestamp":1786642343991,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"National Agency for Scientific and Technological Promotion","doi-asserted-by":"publisher","award":["PICT 2015\u20132168"],"award-info":[{"award-number":["PICT 2015\u20132168"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Subsidio Florencio Fiorini para la Investigaci\u00f3n en Ciencias Biom\u00e9dicas A\u00f1o 2020"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Serum aquaporin-1 increases with inflammation and edema. However, its role as a cardiovascular biomarker remains unexplored. The goal of this study is to evaluate serum aquaporin-1 concentrations across two distinct clinical settings characterized by myocardial stress and congestion: acute heart failure and surgical aortic valve replacement with cardiopulmonary bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This observational study included healthy volunteers (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8), acute heart failure patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11), and surgical aortic valve replacement patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11). Serum aquaporin-1 was measured using ELISA. Myocardial biopsies were obtained for aquaporin-1 and aquaporin-4 protein quantification before and after cardiopulmonary bypass in six patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum aquaporin-1 levels were significantly higher in acute heart failure (3,921 \u00b1 1,396\u00a0pg\/mL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0006) and surgical aortic valve replacement patients (3,318 \u00b1 1,394\u00a0pg\/mL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0070) compared to healthy volunteers (1,755 \u00b1 807\u00a0pg\/mL). These differences remained significant after adjusting for sex and age. All patients with low cardiac output had serum aquaporin-1 concentrations in the upper half of their group distribution. Serum aquaporin-1 correlated moderately with B-type natriuretic peptide (r = 0.40;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0265), C-reactive protein (r = 0.42;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0203), and erythrocyte sedimentation rate (r = 0.45; p = 0.0117). Following cardiopulmonary bypass, myocardial aquaporin-1 increased (73%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0310), while aquaporin-4 decreased (53%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0440), with a strong but non-significant correlation between cardiac and serum aquaporin-1 changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum aquaporin-1 levels are elevated in acute heart failure and post-surgical aortic valve replacement patients, particularly in those with low cardiac output.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261476511","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:21:38Z","timestamp":1786422098000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum aquaporin-1 increases with heart failure and aortic valve surgery with cardiopulmonary bypass"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4158-9080","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Politi","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires"},{"name":"CONICET - Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mail\u00e9n","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanatorio de la Trinidad Mitre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n Ra\u00fal","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanatorio de la Trinidad Mitre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Ferreyra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanatorio de la Trinidad Mitre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Bortman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanatorio de la Trinidad Mitre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanatorio de la Trinidad Mitre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Di Giusto","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires"},{"name":"CONICET - Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Capurro","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires"},{"name":"CONICET - Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-7415-1"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.08.049"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0004563220961752"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.40.11.10417"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3743"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03400-6"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.926957"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.31053\/1853.0605.v81.n2.42432"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005618"},{"key":"e_1_3_8_11_2","first-page":"556","article-title":"Changes in cardiac aquaporin expression during aortic valve replacement surgery with cardiopulmonary bypass","volume":"57","author":"Politi MT","year":"2020","unstructured":"Politi MT, Ochoa F, Netti V, et al. Changes in cardiac aquaporin expression during aortic valve replacement surgery with cardiopulmonary bypass. Eur J Cardio Thorac Surg 2020; 57: 556\u2013564. https:\/\/doi.org\/10.1093\/ejcts\/ezz249","journal-title":"Eur J Cardio Thorac Surg"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00968-1"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25884"},{"key":"e_1_3_8_14_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2025","unstructured":"R Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, 2025. 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