{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:16:59Z","timestamp":1787836619380,"version":"build-2784847793"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe glucose-6-phosphate dehydrogenase (G6PD) deficiency presents unique challenges during cardiopulmonary bypass (CPB) because of increased susceptibility to oxidative injury and haemolysis. Published guidance regarding optimal perfusion management remains limited, particularly in patients with a history of severe haemolytic complications and renal dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technique<\/jats:title>\n                    <jats:p>\n                      A 63-year-old male with severe G6PD deficiency, a previous dialysis-requiring haemolytic crisis, chronic renal impairment and residual hemiparesis following a cerebrovascular accident underwent urgent three-vessel coronary artery bypass grafting. A modified CPB strategy was developed to minimise oxidative stress and mechanical haemolysis. Key components included controlled oxygenation (PaO\n                      <jats:sub>2<\/jats:sub>\n                      approximately 10\u00a0kPa), alpha-stat management, tepid blood cardioplegia, minimisation of cardiotomy suction and blood-air interface exposure, albumin-enriched priming, continuous haemofiltration, and avoidance of oxidant medications, including methylene blue. Oxygen delivery and haematocrit were maintained to support end-organ perfusion and reduce renal hypoxic stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CPB duration was 112\u00a0min, with an aortic cross-clamp time of 76\u00a0min. No clinically significant intravascular haemolysis or haemoglobinuria occurred. Plasma free haemoglobin, bilirubin and lactate dehydrogenase elevations were modest and transient. A single postoperative haemodialysis session was required, after which renal function improved without the need for ongoing renal replacement therapy. The patient was discharged on postoperative day seven without evidence of delayed haemolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A carefully modified CPB strategy focused on reducing oxidative stress, preventing haemolysis and protecting renal function may facilitate successful cardiac surgery in selected patients with severe G6PD deficiency. This report provides a practical perfusion approach for managing patients at exceptionally high risk of peri-operative haemolytic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261485088","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:55:38Z","timestamp":1787666138000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Modified cardiopulmonary bypass strategy for severe glucose-6-phosphate dehydrogenase deficiency during coronary artery bypass grafting: A practical perfusion technique"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-8882","authenticated-orcid":false,"given":"Saeed","family":"Taiyari","sequence":"first","affiliation":[{"name":"Great Ormond Street Hospital NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000944"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0886-0440.2004.04101.x"},{"issue":"11","key":"e_1_3_8_5_2","first-page":"1021","article-title":"Mechanical and inflammatory complications of cardiopulmonary bypass","volume":"43","author":"Undar A","year":"2019","unstructured":"Undar A. Mechanical and inflammatory complications of cardiopulmonary bypass. Artif Organs 2019; 43(11): 1021\u20131032. https:\/\/doi.org\/10.1111\/aor.13544","journal-title":"Artif Organs"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11359"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.02.012"},{"issue":"1","key":"e_1_3_8_8_2","first-page":"109","article-title":"Precautionary measures for successful open heart surgery in G6PD deficiency","volume":"20","author":"Saha S","year":"2017","unstructured":"Saha S, Sachithanandan A, Varghese R, et al. Precautionary measures for successful open heart surgery in G6PD deficiency. Ann Card Anaesth 2017; 20(1): 109\u2013112. https:\/\/doi.org\/10.4103\/0971-9784.197844","journal-title":"Ann Card Anaesth"},{"issue":"1","key":"e_1_3_8_9_2","first-page":"113","article-title":"Impaired oxygenation and increased hemolysis after cardiopulmonary bypass in patients with G6PD deficiency","volume":"82","author":"Gerrah R","year":"2006","unstructured":"Gerrah R, Shargal Y, Elami A. Impaired oxygenation and increased hemolysis after cardiopulmonary bypass in patients with G6PD deficiency. Ann Thorac Surg 2006; 82(1): 113\u2013117. https:\/\/doi.org\/10.1016\/j.athoracsur.2006.02.010","journal-title":"Ann Thorac Surg"},{"key":"e_1_3_8_10_2","unstructured":"White S Reynoso E Pineda L et al. Glucose-6-phosphate dehydrogenase deficiency in the setting of cardiac surgery. In: Poster presented at: California society of anesthesiologists annual meeting Anaheim CA 4\u20137 April 2024."},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/189863"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezae354"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc13991"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001851"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.08.003"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261485088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591261485088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261485088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:18:01Z","timestamp":1787833081000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591261485088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":14,"alternative-id":["10.1177\/02676591261485088"],"URL":"https:\/\/doi.org\/10.1177\/02676591261485088","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"article-number":"02676591261485088"}}