{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:57:18Z","timestamp":1790521038687,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute - Ricerca Corrente","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Veno-venous extracorporeal membrane oxygenation (VV ECMO) is a key therapy for refractory respiratory failure, but can trigger systemic inflammation and prothrombotic activation that impair the membrane lung (ML). ML dysfunction can lead to mechanical failure of extracorporeal support, severe hypoxemia, and the need for urgent or elective circuit replacement. Conventional single parameters (pressure drop, post-ML blood gases, hemoglobin saturation), and laboratory tests have limited ability to predict ML deterioration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single-center pilot retrospective study including 27 ECMO circuits from 20 adult patients with COVID-19\u2013related acute respiratory failure. Membrane lung dead space (DS\n                      <jats:sub>ML<\/jats:sub>\n                      ) was calculated from ML exhaust carbon dioxide (CO\n                      <jats:sub>2<\/jats:sub>\n                      ) and blood gas measurements and used to assess ML effectiveness. For each circuit we evaluated the association between DS\n                      <jats:sub>ML<\/jats:sub>\n                      and subsequent circuit exchange.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      20 patients (27 ECMO circuits) were analyzed; 10 circuits required replacement. Circuits that were replaced showed higher DS\n                      <jats:sub>ML<\/jats:sub>\n                      values and lower CO\n                      <jats:sub>2<\/jats:sub>\n                      concentration in membrane lung exhaust gas and membrane lung CO\n                      <jats:sub>2<\/jats:sub>\n                      removal compared with circuits that completed the run. CO\n                      <jats:sub>2<\/jats:sub>\n                      -derived variables were the only parameters that differed significantly between groups, while oxygenation-related measures and baseline characteristics were similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this exploratory study conducted on COVID-19 patients, we found an association between DS\n                      <jats:sub>ML<\/jats:sub>\n                      increase and membrane lung impairment. However, the analysis does not provide enough information to assess the predictive performance of DS\n                      <jats:sub>ML<\/jats:sub>\n                      . The identification of a significant threshold for circuit exchange requires further validation in larger prospective and multicenter studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261487320","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:38:58Z","timestamp":1790188738000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Membrane lung dead space and membrane lung impairment: An exploratory retrospective study in COVID-19 patients"],"prefix":"10.1177","author":[{"given":"Giovanni","family":"Lino","sequence":"first","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2473-6357","authenticated-orcid":false,"given":"Matteo","family":"Rossetti","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Capitanio","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Coppolecchia","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Longo","sequence":"additional","affiliation":[{"name":"IRCCS-ISMETT, UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Tuzzolino","sequence":"additional","affiliation":[{"name":"Istituto Mediterraneo per i trapianti e Terapie ad alta specializzazione (IRCCS-ISMETT)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Arcadipane","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-2414","authenticated-orcid":false,"given":"Gennaro","family":"Martucci","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-3404","authenticated-orcid":false,"given":"Marta Velia","family":"Antonini","sequence":"additional","affiliation":[{"name":"MSc ECMO Team - Bufalini Hospital"},{"name":"University of Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-2045","authenticated-orcid":false,"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre (MUMC)"},{"name":"Cardiovascular Research Institute Maastricht (CARIM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Panarello","sequence":"additional","affiliation":[{"name":"IRCCS ISMETT"},{"name":"UPMC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202303-0558WS"},{"issue":"9","key":"e_1_3_5_3_2","first-page":"1674","article-title":"Extracorporeal life support for adult patients with ARDS","volume":"51","author":"Combes A","year":"2025","unstructured":"Combes A, Supady A, Abrams D, et al. 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