{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:28:29Z","timestamp":1792772909217,"version":"4.5.0"},"reference-count":5,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Maoming Engineering & Technology Research Center","award":["2026-003"],"award-info":[{"award-number":["2026-003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Perfusion"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients undergoing left ventricular assist device (LVAD) implantation often present with end-stage heart failure, severe pulmonary hypertension, and systemic inflammation. During this procedure, cardiopulmonary bypass (CPB) acts as a double-edged sword: it provides essential life support but can exacerbate right ventricular (RV) dysfunction and trigger severe vasoplegia. Despite the critical nature of the transition from CPB to mechanical support, there is a lack of standardized, phase-specific CPB management protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on current guidelines, frontline perfusion experience, and an interdisciplinary approach integrating mechanical engineering principles with surgical practice, a comprehensive clinical framework for CPB management was developed. The protocol deconstructs the procedure into four distinct phases: pre-bypass assessment, on-bypass management, weaning, and post-bypass care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A four-stage standardized checklist and an intraoperative emergency quick reference card were created to facilitate clinical translation. Key interventions include identifying anatomical \u201cminefields,\u201d maintaining a golden balance of hemodilution, executing a dynamic flow-speed handover to prevent suction events, and managing hemodynamics cautiously during protamine administration to mitigate RV dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Standardizing CPB management during LVAD implantation provides a practical tool to optimize hemodynamic stability and improve perioperative safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02676591261500986","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:36:01Z","timestamp":1792614961000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Standardizing cardiopulmonary bypass management for left ventricular assist device implantation: A clinical framework and checklist"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-4611","authenticated-orcid":false,"given":"Li","family":"Deng","sequence":"first","affiliation":[{"name":"The People's Hospital of Gaozhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2059-6417","authenticated-orcid":false,"given":"Chengbin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"8","key":"e_1_3_3_2_2","first-page":"799","article-title":"Chinese expert consensus on preoperative evaluation and management of candidates for left ventricular assist devices (2023)","volume":"38","author":"CCoEoVA Devices","year":"2023","unstructured":"CCoEoVA Devices. Chinese expert consensus on preoperative evaluation and management of candidates for left ventricular assist devices (2023). Chin Circ J 2023; 38(8): 799\u2013813, [in Chinese].","journal-title":"Chin Circ J"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0645-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz098"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.10.010"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261500986","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02676591261500986","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02676591261500986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:57:05Z","timestamp":1792763825000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02676591261500986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":5,"alternative-id":["10.1177\/02676591261500986"],"URL":"https:\/\/doi.org\/10.1177\/02676591261500986","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"article-number":"02676591261500986"}}