{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:37:22Z","timestamp":1777916242316,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>Mannitol is often included in the priming solution of the heart-lung machine used during cardiopulmonary bypass (CPB). This study was set up to evaluate the effect of different doses of mannitol on human patients. Patients receiving 10 g of mannitol ( n = 18) had an increased diuresis only during the bypass period (mean time = 87 min) when compared with a control group ( n = 19) who did not receive mannitol. Patients receiving 20 g of mannitol ( n = 19) had a significantly greater diuresis than both the control group and the 10 g group and the diuresis continued on throughout the immediate postbypass period (total mean time approximately 3 h). Patients receiving 30 g of mannitol ( n = 20) also had a significantly greater diuresis that continued on during the first hour in the intensive care unit (ICU) (total mean time approximately 4 h). After 6 h in the ICU, all three groups of mannitol-treated patients equally demonstrated a trend towards an increased diuresis over the control group, which became a significant increase by 12 h in the ICU ( p = 0.001) despite indications that the mannitol had been cleared from the body. These results suggest that there is an improvement of renal function post-CPB if mannitol is included in the CPB prime which may be due to an amelioration of the ischaemic effects of bypass on the kidneys.<\/jats:p>","DOI":"10.1177\/026765919801300305","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T17:18:45Z","timestamp":1358961525000},"page":"181-186","source":"Crossref","is-referenced-by-count":36,"title":["The influence of mannitol on renal function during and after open-heart surgery"],"prefix":"10.1177","volume":"13","author":[{"given":"A R","family":"Fisher","sequence":"first","affiliation":[{"name":"Heart Lung Department, Harefield Hospital, Harefield, Middlesex"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jones","sequence":"additional","affiliation":[{"name":"Heart Lung Department, Harefield Hospital, Harefield, 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