{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:37:51Z","timestamp":1777916271413,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Perfusion"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>\n                    Heparin resistance (HR) is a common event in cardiac operations. At present, no clear recognition of the risk factors for HR has been reached. The aim of this study was to determine a predictive model for HR, based on the preoperative patient\u2019s profile. Two hundred consecutive patients scheduled for elective coronary artery bypass operations were enrolled in a prospective trial. Demographics, type of preoperative anticoagulation therapy and preoperative coagulation profile were collected and statistically analysed with respect to the evidence of a HR. Heparin resistance was defined as at least one activated clotting time &lt; 400 s after heparinization and\/or the need for purified antithrombin III (AT-III) administration. With a multivariate analysis we could identify five predictors for HR: AT-III \u2264 60%; preoperative subcutaneous heparin therapy; intravenous heparin therapy; platelet count \u2265 300 000 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    ; age \u2265 65 years. We conclude that HR is a predictable event. In the presence of all the risk factors, the likelihood of HR is 99%; in the absence of all of them, it is 10%. Predicting HR allows us to apply many possible therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1177\/026765919901400606","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T17:18:45Z","timestamp":1358961525000},"page":"437-442","source":"Crossref","is-referenced-by-count":93,"title":["Predictors for heparin resistance in patients undergoing coronary artery                 bypass grafting"],"prefix":"10.1177","volume":"14","author":[{"given":"Marco","family":"Ranucci","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Anaesthesia, University of Milan, San Donato                         Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Isgr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Anaesthesia, University of Milan, San Donato Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Anaesthesia, University of Milan, San Donato Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Soro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Anaesthesia, University of Milan, San Donato Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Menicanti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cardiovascular Centre E. Malan, University                         of Milan, San Donato Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Frigiola","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cardiovascular Centre E. Malan, University                         of Milan, San Donato Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37564-6"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1980.tb05092.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/73.5.723"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005516"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1979.01370260019002"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(20)31420-3"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)91359-5"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36215-4"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(81)90113-4"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830080311"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(77)90084-6"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1979.10481038"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90752-8"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199709000-00005"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91429-5"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)41500-6"},{"key":"atypb17","first-page":"238","volume":"74","author":"Horne MK","year":"1989","journal-title":"Blood"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90029-H"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649589"}],"container-title":["Perfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026765919901400606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/026765919901400606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:43:41Z","timestamp":1777657421000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/026765919901400606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["10.1177\/026765919901400606"],"URL":"https:\/\/doi.org\/10.1177\/026765919901400606","relation":{},"ISSN":["0267-6591","1477-111X"],"issn-type":[{"value":"0267-6591","type":"print"},{"value":"1477-111X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}