{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:49:31Z","timestamp":1792727371887,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although cilostazol, a phosphodiesterase 3 inhibitor, has been suggested to strengthen the endothelial barrier using cultured endothelial monolayers, its effect has not been tested in\u00a0vivo. We, therefore, investigated effects of cilostazol on barrier properties of postcapillary venules of the rat in situ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cilostazol was administered to the rats through oral gavage at 4 hours before the measurements. The hydraulic permeability ( L\n                      <jats:sub>p<\/jats:sub>\n                      ) and the effective osmotic pressure (\u03c3\u0394\u03c0), molecular sieving properties of microvascular walls, were estimated in single mesenteric postcapillary venules by a micro-occlusion technique, first during control perfusion and then in the presence of histamine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When the vessels were inflamed with histamine, cilostazol attenuated a transient increase in L\n                      <jats:sub>p<\/jats:sub>\n                      and prevented \u03c3\u0394\u03c0 from falling. Furthermore, it reduced baseline L\n                      <jats:sub>p<\/jats:sub>\n                      under a control state.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cilostazol appears to tighten the endothelial barrier in situ, at least in part by inhibiting the cAMP-degrading enzyme in the endothelium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0268355513497361","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T21:51:50Z","timestamp":1373925110000},"page":"594-599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Cilostazol strengthens the endothelial barrier of postcapillary venules from the rat mesentery\n                    <i>in situ<\/i>"],"prefix":"10.1177","volume":"29","author":[{"given":"Yasoo","family":"Sugiura","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan"},{"name":"National Hospital Organization, Kanagawa National Hospital, Pulmonary and Thoracic Surgery, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan"},{"name":"Japan Science and Technology Agency, Exploratory Research for Advanced Technology (ERATO), Suematsu Gas Biology Project, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Takenouchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan"},{"name":"Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suematsu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan"},{"name":"Japan Science and Technology Agency, Exploratory Research for Advanced Technology (ERATO), Suematsu Gas Biology Project, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Kajimura","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan"},{"name":"Japan Science and Technology Agency, Exploratory Research for Advanced Technology (ERATO), Suematsu Gas Biology Project, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,7,15]]},"reference":[{"key":"bibr1-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.01.022"},{"key":"bibr2-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70198-8"},{"key":"bibr3-0268355513497361","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.52.471"},{"key":"bibr4-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2006.10.010"},{"key":"bibr5-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-012-9896-1"},{"key":"bibr6-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1159\/000139193"},{"key":"bibr7-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1241-1_12"},{"key":"bibr8-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.3.703"},{"key":"bibr9-0268355513497361","first-page":"1124","volume":"35","author":"Akiyama H","year":"1985","journal-title":"Arzneimittelforschung"},{"key":"bibr10-0268355513497361","first-page":"1144","volume":"35","author":"Kimura T","year":"1985","journal-title":"Arzneimittelforschung"},{"key":"bibr11-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221783.08037.a9"},{"key":"bibr12-0268355513497361","first-page":"283","volume":"59","author":"Michel CC","year":"1974","journal-title":"Q J Exp Physiol Cogn Med Sci"},{"key":"bibr13-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602106"},{"key":"bibr14-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1995.sp003853"},{"key":"bibr15-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.1.308"},{"key":"bibr16-0268355513497361","first-page":"H1885","volume":"274","author":"Adamson RH","year":"1998","journal-title":"Am J Physiol"},{"key":"bibr17-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.201aa.x"},{"key":"bibr18-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119658109"},{"key":"bibr19-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02212.x"},{"key":"bibr20-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-123620"},{"key":"bibr21-0268355513497361","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.57.196"},{"key":"bibr22-0268355513497361","doi-asserted-by":"publisher","DOI":"10.1038\/2121258a0"}],"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0268355513497361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0268355513497361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0268355513497361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:45:29Z","timestamp":1777657529000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0268355513497361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,15]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1177\/0268355513497361"],"URL":"https:\/\/doi.org\/10.1177\/0268355513497361","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"value":"0268-3555","type":"print"},{"value":"1758-1125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,15]]}}}