{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:40:31Z","timestamp":1777916431344,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this analysis was to perform a meta-analysis evaluating gender difference of delayed healing risk in patients with venous leg ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the PubMed and Web of Knowledge from their inception to 4 July 2015. The meta-analysis of pooled odds ratio and 95% confidence interval for venous leg ulcers healing risk were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies with 4453 patients were included in the meta-analysis. The pooled odds ratio for healing rate stratified by gender was 1.055 (95% CI 0.955\u20131.165; Z\u2009=\u20091.05, p\u2009=\u20090.292) by fix-effects model. The Begg's test (z\u2009=\u20092.67, p\u2009=\u20090.007), the Egger's test (t\u2009=\u20094.00, p\u2009=\u20090.003), and asymmetric funnel plot suggested there was significant publication bias. Subgroup analysis showed the pooled odds ratios were 1.048 (95% CI 0.945\u20131.162; Z\u2009=\u20090.88, p\u2009=\u20090.376) in prospective studies and 1.439 (95% CI 0.757\u20132.736; Z\u2009=\u20091.11, p\u2009=\u20090.266) in retrospective studies. Sensitivity analyses by only pooled adjusted odds ratios showed the pooled odds ratio was 1.049 (95% CI 0.946\u20131.163; Z\u2009=\u20090.91, p\u2009=\u20090.365), which indicated the results of meta-analysis were robust. Meta-regression analysis showed the healing rate odds ratio stratified by gender was not related with healing rate (t\u2009=\u20090.73, p\u2009=\u20090.484).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our meta-analysis indicates that no gender difference existed for delayed healing in venous leg ulcers. Our results may be also useful in developing a risk score for failure of venous leg ulcers to heal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0268355515616702","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T22:10:49Z","timestamp":1448057449000},"page":"744-752","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Meta-analytic approaches to determine gender differences for delayed healing in venous leg ulcers"],"prefix":"10.1177","volume":"31","author":[{"given":"Xiao-Lei","family":"Tang","sequence":"first","affiliation":[{"name":"Department of general surgery, Affiliated Hospital of Nantong University, Jiangsu Province, China PR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong University, Nantong City, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nantong University, Nantong City, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"bibr1-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6045"},{"key":"bibr2-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.07.020"},{"key":"bibr3-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2007.02034.x"},{"key":"bibr4-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05568.x"},{"key":"bibr5-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130103.x"},{"key":"bibr6-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"bibr7-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012207.x"},{"key":"bibr8-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12570"},{"key":"bibr9-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.11.069"},{"key":"bibr10-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.10.002"},{"key":"bibr11-0268355515616702","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2005.14.1.26723"},{"key":"bibr12-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1177\/026835550001500202"},{"key":"bibr13-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.8.920"},{"key":"bibr14-0268355515616702","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.3.26381"},{"key":"bibr15-0268355515616702","doi-asserted-by":"publisher","DOI":"10.1177\/1534734614545872"},{"key":"bibr16-0268355515616702","unstructured":"GA Wells, B Shea, D O'Connell, et\u00a0al. 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