{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:40:40Z","timestamp":1777916440543,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate the efficiency of O-(beta-Hydroxyethyl)-rutosides (Oxerutin) in reducing the incidence of venous system disease among patients with calf muscle pump dysfunction secondary to immobilization due to lower-limb fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 60 patients with lower-limb fractures and immobilized in plaster casts were included in this study randomized into control (n\u2009=\u200930; mean: 30.37\u2009\u00b1\u20096.03 years; 73.3% males; no treatment) and experiment (n\u2009=\u200930; mean: 31.67\u2009\u00b1\u20094.76 years; 66.6% males; Oxerutin, 500\u2009mg po q12hr) treatment groups. Doppler ultrasound was performed to evaluate the effect of oxerutin on the alterations in the venous circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients in the control group were determined to be more commonly affected from the below-knee immobilization in terms of venous dysfunction in the great saphenous vein in the below-knee region when compared with the patients in the oxerutin treatment group (46.7 vs. 13.3%, respectively; p\u2009=\u20090.011). Incidence of reflux in the small saphenous vein was more common in the control group during the healing period when compared with the experiment group (40.0 vs. 10.0%, respectively; p\u2009=\u20090.017). None of the patients developed venous thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, the impairment of the lower extremity muscle pump should be considered as an important risk factor for venous disease, and should be evaluated. O-(beta-Hydroxyethyl)-rutosides during 6\u20138 week cast immobilization for a lower limb fracture may be an effective prophylactic regimen in reducing the incidence of reflux in the below-knee superficial veins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0268355516635466","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T21:03:29Z","timestamp":1456693409000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction"],"prefix":"10.1177","volume":"32","author":[{"given":"Cenk Eray","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Istanbul University Institute of Cardiology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenk","family":"Conkbayir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Near East University Faculty of Medicine, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldeniz","family":"Huseynov","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer Ali","family":"Sayin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Istanbul University Medical Faculty, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okan","family":"Tok","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Kaynak","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Cebi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Ugurlucan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Istanbul University Medical Faculty, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muharrem","family":"Inan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"bibr1-0268355516635466","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2011.05.004"},{"key":"bibr2-0268355516635466","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00059-2"},{"key":"bibr3-0268355516635466","first-page":"10","volume":"1","author":"Haenen 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