{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:12:06Z","timestamp":1791209526200,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p\u2009=\u20090.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0268355517718760","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T17:36:20Z","timestamp":1500053780000},"page":"658-664","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Prediction of venous wound healing with laser speckle imaging"],"prefix":"10.1177","volume":"32","author":[{"given":"Timme MAJ","family":"van Vuuren","sequence":"first","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Van Zandvoort","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat","family":"Doganci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, G\u00fclhane School of Medicine, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineke","family":"Zwiers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina J","family":"tenCate-Hoek","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands"},{"name":"Department of Thrombosis, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph LM","family":"Kurstjens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands"},{"name":"Department of Obstetrics and Gynaecology, Haga Hospital, The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees HA","family":"Wittens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands"},{"name":"Department of Vascular Surgery, University Hospital RWTH Aachen, Nordrhein-Westfalen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"bibr1-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-44"},{"key":"bibr2-0268355517718760","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.Sup6.S1"},{"key":"bibr3-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6584.1389"},{"key":"bibr4-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14568677"},{"key":"bibr5-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05568.x"},{"key":"bibr6-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1177\/0268355516632998"},{"key":"bibr7-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.01.004"},{"key":"bibr8-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2012.00205.x"},{"key":"bibr9-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-011-0856-6"},{"key":"bibr10-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1177\/0268355513477025"},{"key":"bibr11-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2016.02.015"},{"key":"bibr12-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.05.012"},{"key":"bibr13-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0626-3"},{"key":"bibr14-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2016.01.005"},{"key":"bibr15-0268355517718760","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.20.e126"}],"container-title":["Phlebology: 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