{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:31:10Z","timestamp":1791815470022,"version":"4.3.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Thuasne"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy, safety and acceptability of an innovative two-component versus a well-established four-component compression systems in the management of venous leg ulcer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Multicentre randomized controlled trial in patients with active venous leg ulcer. Patients were followed-up monthly for a maximum of 16 weeks. The primary endpoint was the complete healing rate at 16 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-two patients were randomized to either the two-component BIFLEX\u00ae Kit group ( n\u2009=\u200949) or the four-component PROFORE\u00ae group ( n\u2009=\u200943). In the full analysis set ( n\u2009=\u200988), a complete healing rate of 48.9% and 24.4% was reported in BIFLEX\u00ae Kit versus PROFORE\u00ae groups, respectively (i.e. a superiority of 24.5%, p\u2009=\u20090.02). Acceptability of BIFLEX\u00ae Kit was higher from both the patients\u2019 and physicians\u2019 perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The BIFLEX\u00ae Kit represents a valid alternative therapy in the management of venous leg ulcer according to its clinical efficacy, safety and acceptability with potential positive impacts on healthcare costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0268355519833523","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T20:38:05Z","timestamp":1551818285000},"page":"611-620","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial"],"prefix":"10.1177","volume":"34","author":[{"given":"Jean L","family":"Gillet","sequence":"first","affiliation":[{"name":"Cabinet M\u00e9dical, Bourgoin-Jallieu, Is\u00e8re, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean J","family":"Guex","sequence":"additional","affiliation":[{"name":"Cabinet M\u00e9dical, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois A","family":"Allaert","sequence":"additional","affiliation":[{"name":"Chaire d\u2019\u00c9valuation M\u00e9dicale, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Avouac","sequence":"additional","affiliation":[{"name":"Conseil, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Leger","sequence":"additional","affiliation":[{"name":"Centre de Plaies et Cicatrisation, Clinique Pasteur, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Blaise","sequence":"additional","affiliation":[{"name":"Vascular Medicine Department, Grenoble University Hospital, Grenoble, France"},{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Marchand","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Center of Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Maillard","sequence":"additional","affiliation":[{"name":"Dermatology Department, Centre Hospitalier G\u00e9n\u00e9ral, Le Mans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Simon","sequence":"additional","affiliation":[{"name":"Thuasne, Levallois-Perret, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrine B","family":"Amor","sequence":"additional","affiliation":[{"name":"Thuasne, Levallois-Perret, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Thuasne, Levallois-Perret, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"bibr1-0268355519833523","volume-title":"Prise en charge de l\u2019ulc\u00e8re de jambe \u00e0 pr\u00e9dominance veineuse hors pansement. 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Edinburgh, UK."},{"key":"bibr10-0268355519833523","first-page":"193","volume":"27","author":"Partsch H","year":"2008","journal-title":". Int Angiol"},{"key":"bibr11-0268355519833523","unstructured":"HAS. Dispositifs de compression m\u00e9dicale \u00e0 usage individuel, utilisation en pathologies vasculaires (r\u00e9vision de la liste des produits et prestations remboursables). 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