{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:02:09Z","timestamp":1790625729500,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze adverse events (AEs) related to sclerosants reported through the Federal Adverse Event Reporting System (FAERS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried the FAERS database for all cases associated with sclerosants. Reports were analyzed and stratified based on severity of cases and patient death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1215 cases with 3124 reactions were identified among 4 sclerosants. \u201cGeneral disorder and administration site conditions\u201d reaction group was prevalent in all sclerosants. For polidocanol, deep vein thrombosis and pulmonary embolism were the most common severe reactions while cardiac arrest was frequent in death cases. Anaphylaxis was common in fatalities of sodium tetradecyl sulfate. Ethanolamine oleate was associated with procedural errors, while morrhuate sodium resulted in few cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our analysis supports previous studies concerning common local symptoms, but also reveals serious and death associated reaction profiles specific to individual sclerosants. Practitioners should be knowledgeable on both non-lethal and fatal AEs for each sclerosant. The multitude of reports concerning serious reactions and deaths we report herein provide a cautionary reminder to venous practitioners and patients that sclerotherapy is not a trivial procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555221088373","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T12:10:16Z","timestamp":1650456616000},"page":"452-459","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of adverse events with sclerosants reported to the United States Food and Drug Administration"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-445X","authenticated-orcid":false,"given":"Christopher N","family":"Nguyen","sequence":"first","affiliation":[{"name":"School of Medicine, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc-Bao D","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"},{"name":"Department of Dermatology, UTHealth McGovern Medical School, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirunya","family":"Silapunt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, UTHealth McGovern Medical School, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"bibr1-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2017.02.002"},{"key":"bibr2-02683555221088373","volume-title":"Plastic Surgery Statistics Report 2020","author":"American Society of Plastic Surgeons","year":"2020"},{"key":"bibr3-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2017.11.010"},{"key":"bibr4-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1159\/000445436"},{"key":"bibr5-02683555221088373","volume-title":"Federal Drug Administration Adverse Event Reporting System Database","author":"U.S. Federal Drug Administration","year":"2021"},{"key":"bibr6-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14223"},{"key":"bibr7-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256752"},{"key":"bibr8-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1177\/0268355514526532"},{"key":"bibr9-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.06.026"},{"key":"bibr10-02683555221088373","first-page":"2610","volume-title":"Dermatology","author":"Goldman MP","year":"2018","edition":"4"},{"key":"bibr11-02683555221088373","volume-title":"Esophageal Varices","author":"Meseeha M","year":"2021"},{"key":"bibr12-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2007.007073"},{"key":"bibr13-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.06.111"},{"key":"bibr14-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1177\/0268355513497709"},{"key":"bibr15-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1177\/02683555211051490"},{"key":"bibr16-02683555221088373","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002832"},{"key":"bibr17-02683555221088373","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629050-00003"}],"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02683555221088373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02683555221088373","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02683555221088373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:52:54Z","timestamp":1777657974000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02683555221088373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/02683555221088373"],"URL":"https:\/\/doi.org\/10.1177\/02683555221088373","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"value":"0268-3555","type":"print"},{"value":"1758-1125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]}}}