{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:43:55Z","timestamp":1777916635705,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Farmacot\u00e9cnica \u00a9"},{"name":"Medi \u00a9"},{"name":"FEPECS"},{"name":"Sabin Laboratory"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the healing of venous ulcers in the lower limbs (VLU) using dressings with hydrocolloid gel associated with Syzygium cumini extract (SHG) compared to standard hydrocolloid gel dressings (HG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This prospective, double-blind, randomized trial recruited 90 patients with VLU divided into: dressings with SHG ( n = 44) and dressings with HG ( n = 46). Primary endpoint was healing in the 14th visit. Secondary endpoints were healing rate, complete healing during follow-up, and improvement in the pain scale and in quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant between-group differences in healing ( p = 0.15). The wound area made healing difficult ( p = 0.008). Age, body mass index, and wound time demonstrated a tendency to worsen the healing. Positive culture for Pseudomonas aeruginosa resulted in 88% reduction in the healing risk ( p &lt; 0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was no difference between the dressings evaluated. The presence of Pseudomonas aeruginosa significantly impaired wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555221088380","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T05:19:23Z","timestamp":1650863963000},"page":"460-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomized, double-blind clinical trial comparing the healing of stasis ulcers in lower limbs with standard hydrocolloid gel dressings and with dressings with Syzygium cumini extract"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-6676","authenticated-orcid":false,"given":"Gilson Roberto de","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Faculty of Health Science, Federal District Health Department, Vascular Surgery, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-6676","authenticated-orcid":false,"given":"Bruna St\u00e9fany Bento de Sousa","family":"Teles","sequence":"additional","affiliation":[{"name":"Faculty of Health Science, Federal District Health Department, Vascular Surgery, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana Cardoso","family":"Xoteslem","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Secretary of State for Health of the Federal District, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u00eds","family":"Gratieri","sequence":"additional","affiliation":[{"name":"Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Costa","family":"Fortes","sequence":"additional","affiliation":[{"name":"School of Health Sciences (ESCS), Secretary of State for Health of the Federal District, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Novaes","sequence":"additional","affiliation":[{"name":"Faculty of Health Science, Federal District Health Department, Vascular Surgery, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"bibr1-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70330-7"},{"key":"bibr2-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6485.1855"},{"key":"bibr3-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/15.2.210"},{"key":"bibr4-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00284-8"},{"key":"bibr5-02683555221088380","unstructured":"Mayer W, Jochmann W, Partsch H. Varicose ulcer: healing in conservative therapy. A prospective study. Wien Med Wochenschr 1994; 144(10\u201311): 250\u2013252. Available at: http:\/\/europepmc.org\/abstract\/MED\/7856198 (accessed 21 September 2021)."},{"key":"bibr6-02683555221088380","first-page":"CD003557","volume":"1","author":"O\u2019Meara S","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr7-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(97)80015-9"},{"key":"bibr8-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012583.pub2"},{"issue":"11","key":"bibr9-02683555221088380","first-page":"CD000265","volume":"2012","author":"O\u2019meara S","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr10-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6111"},{"key":"bibr11-02683555221088380","doi-asserted-by":"publisher","DOI":"10.4236\/fns.2012.38146"},{"key":"bibr12-02683555221088380","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(12)60050-1"},{"key":"bibr13-02683555221088380","unstructured":"Louise B, Gondim C. 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Outdoor treatment of tail necrosis in piglets with ethanol extract of jambolan (Syzygium cumini L. Skeels): Case report. In: Tratamento de necrose de cauda em leit\u00f5es ao ar livre com extrato etan\u00f3lico de jamel\u00e3o (Syzygium cumini L. Skeels): Relato de caso.] XXIV Symposium on Medicinal Plants of Brazil-2016, Belo Horizonte, 21\u201324 September 2016. 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