{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:44:01Z","timestamp":1777916641597,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012655","name":"Qilu Hospital of Shandong University","doi-asserted-by":"publisher","award":["Development Funding for Novel Clinical Technology"],"award-info":[{"award-number":["Development Funding for Novel Clinical Technology"]}],"id":[{"id":"10.13039\/100012655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the role of hyaluronic acid (HA) in polidocanol (POL) foam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The dose-dependent effect of HA-POL on cultured human umbilical vein endothelial cells (HUVECs) as well as foam stability was evaluated by measuring optical density (OD) values and foam half-life time (FHT), respectively. An in vitro model was utilized for estimating the foam blood-displacement capacity by adopting maximum displacement distance (MDD) and displacement time. A comparison of foam viscosity was also carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The OD values of HUVECs treated with HA first increased and then decreased with the growing dosage of HA while cells treated with HA-POL died. Both FHT and displacement time were prolonged statistically with a gradually enhanced foam viscosity. As to MDD, there were no significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HA was found to promote HUVECs proliferation slightly, but this was almost negligible when compared to the cell-killing capacity of 1% POL. The viscosity of POL foam was enhanced by HA indicating its positive correlation with both stability and displacement capacity of POL foam.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555221129555","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T02:09:52Z","timestamp":1664158192000},"page":"701-708","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of hyaluronic acid in polidocanol foam: An in vitro study"],"prefix":"10.1177","volume":"37","author":[{"given":"Liu","family":"Ziyi","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Plastic and Burn Surgery, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Xuanxuan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan, China"},{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dongjian","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Plastic and Burn Surgery, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Azmoun","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Plastic and Burn Surgery, Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-9243","authenticated-orcid":false,"given":"Liu","family":"Shaohua","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan, China"},{"name":"Institute of Stomatology, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"bibr1-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90467-3"},{"key":"bibr2-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.22.13997"},{"key":"bibr3-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000595"},{"key":"bibr4-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001587"},{"key":"bibr5-02683555221129555","first-page":"58","volume":"27","author":"Tessari L","year":"2001","journal-title":"Dermatol Surg"},{"key":"bibr6-02683555221129555","first-page":"1417","volume":"24","author":"Carugo D","year":"2013","journal-title":"J Mater Sci"},{"key":"bibr7-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1021\/ie50501a040"},{"key":"bibr8-02683555221129555","first-page":"263","volume":"6","author":"Pries AR","year":"1992","journal-title":"Am J Physiol"},{"key":"bibr9-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5b00181"},{"key":"bibr10-02683555221129555","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092485"},{"key":"bibr11-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0462-9"},{"key":"bibr12-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-7709-9_12"},{"key":"bibr13-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1465053"},{"key":"bibr14-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90048-9"},{"key":"bibr15-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-012-2294-1"},{"key":"bibr16-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1097\/00042728-200712000-00006"},{"key":"bibr17-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01832.x"},{"key":"bibr18-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.07.013"},{"key":"bibr19-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.11.056"},{"key":"bibr20-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.02.033"},{"key":"bibr21-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.09.072"},{"key":"bibr22-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1021\/ja01236a045"},{"key":"bibr23-02683555221129555","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12111039"},{"key":"bibr24-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000225"},{"key":"bibr25-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1177\/026835550201700105"},{"key":"bibr26-02683555221129555","first-page":"258","volume":"26","author":"Carugo D","year":"2015","journal-title":"J Mater Sci"},{"key":"bibr27-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2009.009061"},{"key":"bibr28-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2010.010028"},{"key":"bibr29-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1006\/jcis.2002.8592"},{"key":"bibr30-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34681"},{"key":"bibr31-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b00736"},{"key":"bibr32-02683555221129555","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00192"},{"key":"bibr33-02683555221129555","doi-asserted-by":"publisher","DOI":"10.3390\/polym12081800"},{"key":"bibr34-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X14525035"},{"key":"bibr35-02683555221129555","first-page":"399","volume":"7","author":"Lai SW","year":"2008","journal-title":"J Drugs Dermatology"},{"key":"bibr36-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30208.x"},{"key":"bibr37-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1177\/0268355520957202"},{"key":"bibr38-02683555221129555","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.04.005"}],"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02683555221129555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02683555221129555","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02683555221129555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:53:15Z","timestamp":1777657995000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02683555221129555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/02683555221129555"],"URL":"https:\/\/doi.org\/10.1177\/02683555221129555","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"value":"0268-3555","type":"print"},{"value":"1758-1125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,25]]}}}