{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:05:48Z","timestamp":1787018748154,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Foundation for Key Medical Specialty of Nanjing","award":["(SZDZK202001)"],"award-info":[{"award-number":["(SZDZK202001)"]}]},{"name":"Medical Project of Jinling Hospital","award":["(No. 22LCZLXJS4)"],"award-info":[{"award-number":["(No. 22LCZLXJS4)"]}]},{"name":"Medical Project of Jinling Hospital","award":["(No. 22JCYYYB37)"],"award-info":[{"award-number":["(No. 22JCYYYB37)"]}]},{"name":"Medical Project of Jinling Hospital","award":["(No. 22JCYYYB28)"],"award-info":[{"award-number":["(No. 22JCYYYB28)"]}]},{"name":"Natural Science Foundation of Jiangsu Province, China","award":["(No. BK20231504)"],"award-info":[{"award-number":["(No. BK20231504)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Localized intravascular coagulation (LIC) is a unique phenomenon associated with venous malformations (VMs). This study investigated the changes in LIC related indexes following sclerotherapy of VMs and its correlation with therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From August 2019 to September 2023, patients who met the following criteria were enrolled into this study: (1) individuals with venous malformations accompanied by LIC; (2) those who had undergone a minimum of three sclerotherapy sessions; (3) blood coagulation function tests were conducted prior to each treatment; and (4) magnetic resonance imaging (MRI) scans were conducted both before and after three times of treatment. Those who fail to meet with the previous inclusion criteria were excluded. The coagulation profile prior to each sclerotherapy treatments was assessed. The therapeutic outcomes were evaluated at the end of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 21 patients were enrolled into the study, with the age ranging from 4 to 61 years old. Elevated D-dimer levels, with or without a decrease in fibrinogen (FIB) and an increase in fibrin degradation products (FDP) are clinical features of VMs with LIC. The coagulation indexes tend to settle down with several sclerotherapy treatments. There were 5 cases in the significantly improved group, 13 cases in the improved group, and 3 cases in the no improved group when it came to efficacy assessment. The better therapeutic efficacy is more pronounced the improvement of LIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LIC gradually returns to normal during sclerotherapy, and the degree of recovery is directly related to the treatment\u2019s efficacy. One useful metric to evaluate the effectiveness of sclerotherapy for VMs is the improvement of LIC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555241308086","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T21:17:08Z","timestamp":1733865428000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A long-term follow-up study of the changes in localized intravascular coagulation-related indexes after sclerotherapy of venous malformation"],"prefix":"10.1177","volume":"40","author":[{"given":"Miao","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-9391","authenticated-orcid":false,"given":"Yi-Ran","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Li","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Jinling Hospital, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Pei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Plastic Surgery, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Plastic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China"},{"name":"Department of Plastic Surgery, Jinling Hospital, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780195145052.001.0001"},{"issue":"01","key":"e_1_3_3_3_2","first-page":"1","article-title":"CSSIV Guidelines for Vascular Anomalies","volume":"20","author":"Chinese society for the study of vascular anomalies (CSSVA)","year":"2024","unstructured":"Chinese society for the study of vascular anomalies (CSSVA). CSSIV Guidelines for Vascular Anomalies[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2024; 20(01): 1\u201350.","journal-title":"Journal of Tissue Engineering and Reconstructive Surgery"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.7.873"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-015-3389-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00558.x"},{"issue":"01","key":"e_1_3_3_7_2","first-page":"28","article-title":"Absolute ethanol versus foam hardening agent for large venous malformations in child patients: comparison of the efficacy","volume":"33","author":"Zhao L","year":"2024","unstructured":"Zhao L, Ding Y, Xu WY, et al. Absolute ethanol versus foam hardening agent for large venous malformations in child patients: comparison of the efficacy[J]. J Interv Radiol,2024,33(01):28-32.","journal-title":"J Interv Radiol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0803-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14238"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29610"},{"issue":"02","key":"e_1_3_3_11_2","first-page":"123","article-title":"The clinical effect of DSA-guided percutaneous sclerotherapy using 3% polidocanol combined with absolute ethanol in the treatment of venous malformation of limbs","volume":"32","author":"Wang SZ","year":"2023","unstructured":"Wang SZ, Zhao WP, Zhou WM. The clinical effect of DSA-guided percutaneous sclerotherapy using 3% polidocanol combined with absolute ethanol in the treatment of venous malformation of limbs[J]. 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