{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:13:57Z","timestamp":1789431237876,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Postsclerotherapy hyperpigmentation (PSH) is a common side effect of sclerotherapy that can persist in a small proportion of patients. Up to now, hemosiderin has been the only histologically proven causative pigment, making laser treatment the primary therapeutic option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to identify the origin of pigment in post-sclerotherapy hyperpigmentation based on histopathological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 20 skin biopsies from 19 patients including identification of the type of pigment and pigment location. 10 biopsies were taken from patients with PSH &gt;3\u00a0months and 10 from those with PSH &lt;3\u00a0months. The analyses included hematoxylin-eosin, Prussian blue, Masson-Fontana and CD68 staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hemosiderin was detected in all biopsies, predominantly in the reticular dermis and in the subcutis, with a particular prevalence in newer PSH cases. Epidermal melanin was enhanced in three patients, whereas dermal melanin was increased in seven patients, three of whom also exhibited a decrease in epidermal pigment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hemosiderin and postinflammatory hyperpigmentation with increased dermal or epidermal melanin contribute to the development of PSH in some patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555251357095","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T08:31:54Z","timestamp":1751272314000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Revealing the origin of postsclerotherapy hyperpigmentation: Identification of melanin and hemosiderin as causative pigments in a histopathological study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-302X","authenticated-orcid":false,"given":"Simon","family":"Bossart","sequence":"first","affiliation":[{"name":"University of Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert-Adrien","family":"Ramelet","sequence":"additional","affiliation":[{"name":"University of Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6466-2199","authenticated-orcid":false,"given":"S Morteza","family":"Seyed Jafari","sequence":"additional","affiliation":[{"name":"University of Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Yawalkar","sequence":"additional","affiliation":[{"name":"University of Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Feldmeyer","sequence":"additional","affiliation":[{"name":"University of Bern"},{"name":"University Teaching and Research Hospital of the University of Lucerne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-6086","authenticated-orcid":false,"given":"Kristine","family":"Heidemeyer","sequence":"additional","affiliation":[{"name":"University of Bern"},{"name":"University Teaching and Research Hospital of the University of Lucerne"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18639"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01182.x"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1987.tb00940.x"},{"issue":"1","key":"e_1_3_7_5_2","first-page":"31","article-title":"Les complications de la micro-scl\u00e9roth\u00e9rapie des t\u00e9langiectasies","volume":"63","author":"Kern P","year":"2010","unstructured":"Kern P. Les complications de la micro-scl\u00e9roth\u00e9rapie des t\u00e9langiectasies. Phlebologie 2010; 63(1): 31\u201336.","journal-title":"Phlebologie"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/02683555231196702"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1990.tb01563.x"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000568"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03123.x"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99268.x"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1992.tb03695.x"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2011.10.005"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2017.207"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01369823"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3503"},{"key":"e_1_3_7_16_2","first-page":"120347542412657","article-title":"Treatment of post-inflammatory hyperpigmentation in skin of colour: a systematic review","author":"Mar K","year":"2024","unstructured":"Mar K, Khalid B, Maazi M, et al. Treatment of post-inflammatory hyperpigmentation in skin of colour: a systematic review. J Cutan Med Surg 2024: 12034754241265716.","journal-title":"J Cutan Med Surg"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.13038"},{"issue":"7","key":"e_1_3_7_18_2","first-page":"20","article-title":"Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis EC","year":"2010","unstructured":"Davis EC, Callender VD. Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. 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