{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:08:34Z","timestamp":1789416514110,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Vein Clinics of Lake County LLC"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Symptoms of Orthostatic Hypotension have been well-documented for decades, but identifying the cause is often elusive. While many cases are attributed to autonomic dysfunction, drug side effects, and systemic diseases, there remain a significant number of cases where a clear etiology is not found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of 646 patients at our vein clinics with venous insufficiency were retrospectively reviewed from 2013 to 2019. Orthostatic vitals were measures at initial visit and post venous ablations. We measured the degree of decrease in systolic BP, diastolic BP, and increase in heart rate associated with change of position from sit to stand. Positive orthostatic was assigned for systolic drop of 20 mmHg or diastolic drop of 10 mmHg or heart rate increase of 10 bpm. Patients had their initial and final vital sign fluctuations analyzed with statistical regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 178 positive patients out of 646 total), 59 showed a Systolic drop of 20 mmHg or greater, 24 showed a Diastolic drop of 10 mmHg or greater, and 123 showed a rise in HR by 10 bpm or greater. Data regression showed that after ablative vein treatments, the magnitude of drop in BP (systolic or diastolic), or increase in HR, were significantly reduced (systolic pressure (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2264 0.001), diastolic pressure (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2264 0.001), and heart rate spike (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2264 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggests that venous ablative leg vein treatments might play a significant role in improving orthostatic vital signs. Venous assessment and treatment may offer a potential therapeutic avenue for patients with resistant orthostatic intolerance. However, venous insufficiency needs more investigation in patients with OH to further understand the underlying physiological mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555251358925","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T11:20:02Z","timestamp":1752319202000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential relationship between chronic venous insufficiency and orthostatic hypotension"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9786-7236","authenticated-orcid":false,"given":"Raz","family":"Arman","sequence":"first","affiliation":[{"name":"Tulane University School of Medicine"},{"name":"Vein Clinics of Lake County"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0223-1480","authenticated-orcid":false,"given":"Mohseni","family":"Razieh","sequence":"additional","affiliation":[{"name":"Vein Clinics of Lake County"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shengping","sequence":"additional","affiliation":[{"name":"Lousiana Clinical and Translational Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pustay","family":"Courtney","sequence":"additional","affiliation":[{"name":"Vein Clinics of Lake County"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collins","family":"Tina","sequence":"additional","affiliation":[{"name":"Vein Clinics of Lake County"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1084"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.02.023"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2016135"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102446"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.32.2.213"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.10.012"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu162"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005994"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.052"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13242"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.16.03639-7"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2014.07.009"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.07.008"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/02683555231219737"},{"key":"e_1_3_6_16_2","article-title":"Pelvic venous disorders (PeVD): pre- and post-treatment symptom assessment \u2013 results from a prospective multi-site clinical trial","author":"Knuttinen MG","year":"2024","unstructured":"Knuttinen MG, Pelvic venous disorders (PeVD): pre- and post-treatment symptom assessment \u2013 results from a prospective multi-site clinical trial. 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