{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:55:29Z","timestamp":1781906129069,"version":"3.54.5"},"reference-count":56,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"KCI USA Inc. San"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Negative pressure wound therapy (NPWT) is a useful adjunct to optimization of wound healing. We aimed to evaluate the benefits of NPWT in the management of refractory non-healing venous leg ulcers (VLU), in conjunction with compression therapy (CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomised controlled trial where 50 patients with chronic VLU were randomised to either NPWT with CT, or to CT alone, on a 1:1 ratio, for 12\u00a0weeks. Sample size was calculated to detect a minimum of 19\u00a0days with a standard deviation of 12 days and a power of 95% (\u03b1 = 5%). Patients were followed-up for 1\u00a0year. Patients with mixed aetiology were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographics, risk factors were similar in both groups. All ulcers were CEAP C\n                      <jats:sub>6,s<\/jats:sub>\n                      .Mean time to full healing was 64.3\u00a0days \u00b14.2\u00a0days in NPWT + CT patients and 83.2\u00a0days \u00b18.4\u00a0days in compression patients (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). At 12\u00a0weeks, 80% of NPWT + CT managed ulcers (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20\/25) were completely healed, compared to 36% of CCD ulcers (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9\/25) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). Mean reduction in ulcer surface area at 12\u00a0weeks was 79% in NPWT + CT patients, compared to 58% in the compression group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). At 12 months follow-up, one recurrence occurred in the NPWT group, compared to two of the compression healed ulcers (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .375). No local or systemic complications were encountered in either treatment group. NPWT + CT participants experienced an improvement in their physical functioning component. Total cost was 80,187.50 euros for NPWT + CT as opposed to 88,135.00 euros for CT participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NPWT reduces healing time, improves wound size reduction, reduce bacterial colonization in VLUs and enhances patient quality of life compared to compression alone. It achieves this while being cost-neutral compared to compression therapy alone with better quality of life by reducing complications and hospital stays.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555251404139","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T13:01:31Z","timestamp":1764334891000},"page":"532-544","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Compression versus bridge negative pressure wound therapy combined with compression in non-healing venous ulcers: A randomized controlled trial with quality-of-life assessment and cost effectiveness"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-7406","authenticated-orcid":false,"given":"Wael","family":"Tawfick","sequence":"first","affiliation":[{"name":"University Hospital Galway"},{"name":"University of Galway"},{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-5911","authenticated-orcid":false,"given":"Yogesh","family":"Acharya","sequence":"additional","affiliation":[{"name":"University Hospital Galway"},{"name":"University of Galway"},{"name":"Royal College of Surgeons in Ireland and University of Galway"},{"name":"Galway Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-0030","authenticated-orcid":false,"given":"Kalliopi-Maria","family":"Tasopoulou","sequence":"additional","affiliation":[{"name":"University Hospital Galway"},{"name":"University of Galway"},{"name":"Royal College of Surgeons in Ireland and University of Galway"},{"name":"Galway Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Cahill-Collins","sequence":"additional","affiliation":[{"name":"University Hospital Galway"},{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gallagher","sequence":"additional","affiliation":[{"name":"University of Galway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Dublin (CVRI Dublin)"},{"name":"Mater Private Network & RCSI University of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8767-4929","authenticated-orcid":false,"given":"Sherif","family":"Sultan","sequence":"additional","affiliation":[{"name":"University Hospital Galway"},{"name":"University of Galway"},{"name":"Royal College of Surgeons in Ireland and University of Galway"},{"name":"Galway Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010182"},{"key":"e_1_3_7_3_2","first-page":"139","article-title":"The multiple benefits of accurate assessment. 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