{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:27:20Z","timestamp":1787095640997,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deep vein thrombosis (DVT) remains a frequent and potentially life-threatening complication among hospitalized patients, necessitating timely diagnosis. The Wells score is widely used for assessing DVT probability; however, its performance in inpatient populations remains uncertain. This study aimed to evaluate the diagnostic accuracy of the Wells criteria for lower extremity DVT among hospitalized patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case\u2013control study conducted at two teaching hospitals between 2017 and 2020, 240 patients with confirmed DVT were compared with 240 age- and sex-matched controls without DVT. All participants underwent standardized clinical evaluation and duplex ultrasonography within 24\u00a0h of admission. Wells scores were calculated based on predefined clinical parameters. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 480 participants (mean age 51.9 \u00b1 11.6\u00a0years; 54.4% female), DVT was confirmed in 240 (50%). A Wells score \u22652 classified patients as likely DVT. This threshold yielded a sensitivity of 86.3%, specificity of 70.0%, PPV of 74.2%, and NPV of 83.8%. Significant predictors included recent surgery or prolonged hospitalization (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), calf swelling &gt;3\u00a0cm (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), and pitting edema confined to the symptomatic leg (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Wells criteria demonstrated good sensitivity and moderate specificity for diagnosing DVT in hospitalized patients, supporting their role as an initial clinical assessment tool. However, they should not replace confirmatory testing such as ultrasonography or D-dimer assays. Larger multicenter studies are warranted to further validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555251409995","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T20:32:15Z","timestamp":1767645135000},"page":"689-695","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic value of the wells score for lower extremity deep vein thrombosis in hospitalized patients: A case\u2013control study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5602-3816","authenticated-orcid":false,"given":"Saeed","family":"Kargar-soleimanabad","sequence":"first","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Najafi","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Godazandeh","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_3_9_2_2","volume-title":"StatPearls","author":"McLendon K","year":"2025","unstructured":"McLendon K, Goyal A, Attia M. 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