{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:38:18Z","timestamp":1793104698817,"version":"4.5.0"},"reference-count":111,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Compression pressure is the key factor determining effectiveness in compression therapy for venous and lymphatic disorders. Despite its clinical importance, few studies report the actual applied pressure, and national standards for compression classes differ. This review aims to identify the optimal compression pressure at different stages of venous disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted in PubMed, Scopus, and Web of Science (January 1980\u2013October 2025) using MeSH terms related to compression therapy and chronic venous disease, edema, thrombosis, post-thrombotic syndrome, lipedema, and lymphedema. Only English-language studies reporting compression pressure or class were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Low pressures (10\u201321\u00a0mmHg) are enough to relieve symptoms in CEAP C0s\u2013C1. For uncomplicated varicose veins (C2), 18\u201332\u00a0mmHg offers optimal symptom control. In venous edema (C3), pressures of 15\u201321\u00a0mmHg help prevent edema, while around 40\u00a0mmHg is more effective for treatment. Lipodermatosclerosis (C4) requires about 40\u00a0mmHg, and healed ulcers (C5) benefit from pressures greater than 30\u00a0mmHg to prevent recurrence, although compliance decreases with higher pressures. Active ulcers (C6) heal fastest under 40\u201350\u00a0mmHg, preferably with short-stretch materials or adjustable wraps. For lymphedema, effective reduction occurs at more than 50\u00a0mmHg (up to 120\u00a0mmHg briefly), while in the maintenance phase, 23\u201332\u00a0mmHg with flat-knit garments may be enough. Data on thrombosis, post-thrombotic syndrome, and post-procedure compression remain inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Optimal compression pressure depends on disease severity. Early CVD stages and lipedema benefit from a compression pressure &lt;30\u00a0mmHg, while severe venous or lymphatic disease requires \u226540\u00a0mmHg. Standardized reporting and pressure-based recommendations are essential to improve therapeutic consistency and patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555251410002","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:38:39Z","timestamp":1766486319000},"page":"600-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["What is the recommended compression pressure for different clinical indications?"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-8463","authenticated-orcid":false,"given":"Giovanni","family":"Mosti","sequence":"first","affiliation":[{"name":"MD Barbantini Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Patrick","family":"Benigni","sequence":"additional","affiliation":[{"name":"Department de P\u00e9dagogie, CHU Piti\u00e9 Salpetriere, Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5322-2190","authenticated-orcid":false,"given":"Alberto","family":"Caggiati","sequence":"additional","affiliation":[{"name":"Facolt\u00e0 Interdipartimentale di Medicina e Chirurgia, Campus Biomedico University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.12.075"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2008.008014"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2011.011108"},{"key":"e_1_3_5_5_2","first-page":"383","article-title":"Efficacy of class 1 elastic compression stockings in the early stages of chronic venous disease: a comparative study","volume":"22","author":"Benigni JP","year":"2003","unstructured":"Benigni JP, Sadoun S, Allaert FA, et al. 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