{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:46:25Z","timestamp":1777916785398,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of Autologous Platelet-Rich Fibrin (PRF) versus Normal Saline (NS) dressings in healing Chronic Venous Leg Ulcers (CVLUs), focusing on ulcer area reduction and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized controlled trial was conducted at a tertiary care center involving 74 patients with chronic venous leg ulcers (CVLUs). Patients were randomized into two groups: Group A (n = 36) received autologous platelet-rich fibrin (PRF) dressings with four-layer compression therapy, while Group B (n = 38) received Normal Saline (NS) dressings with four-layer compression therapy. Ulcer area and Quality of Life were assessed at baseline and at predefined intervals up to 4\u00a0weeks, with continued follow-up for 6\u00a0months. The quality of life was assessed using the Charing Cross Venous Ulcer Questionnaire (CCVUQ) and the EuroQol-5 Dimension-5 Level (EQ-5D-5L) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups showed a reduction in ulcer area over time. In the PRF group, mean ulcer area decreased significantly from baseline to 4\u00a0weeks (17.46 \u00b1 11.52\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      to 9.92 \u00b1 8.73\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      ; p = 0.007), whereas the reduction in the saline group was not statistically significant (14.07 \u00b1 14.43\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      to 11.45 \u00b1 12.02\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      ; p = 0.913). Between-group comparison at 4\u00a0weeks was not significant; however, from 4\u00a0weeks onward, the PRF group consistently demonstrated smaller mean ulcer areas, with the greatest difference observed at 6\u00a0months. CCVUQ and EQ-5D-5L scores improved over time in both groups, with a transient between-group difference favoring PRF at 4\u00a0weeks for CCVUQ but no sustained head-to-head superiority in quality-of-life outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autologous PRF, when used as an adjunct to standard compression therapy, is associated with earlier and sustained reduction in ulcer area and improvement in ulcer-related Quality-of-Life in patients with chronic venous leg ulcers. No treatment related adverse events were observed during the study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555261433271","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:00:36Z","timestamp":1773313236000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of autologous platelet-rich fibrin compared to normal saline in the management of chronic venous leg ulcers: A randomized controlled trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-6145","authenticated-orcid":false,"given":"Pallaprolu","family":"Jyothirmai","sequence":"first","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra Kumar","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumya","family":"Singh","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulika","family":"Chandra","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailendra Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna Kant","family":"Singh","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav Arun","family":"Sonkar","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-018-0119-y"},{"issue":"5","key":"e_1_3_6_3_2","first-page":"298","article-title":"Venous ulcers: diagnosis and treatment","volume":"100","author":"Bonkemeyer MS","year":"2019","unstructured":"Bonkemeyer MS, Gan R, Townsend PE. Venous ulcers: diagnosis and treatment. Am Fam Physician 2019; 100(5): 298\u2013305.","journal-title":"Am Fam Physician"},{"issue":"7","key":"e_1_3_6_4_2","first-page":"e26829","article-title":"The efficacy of platelet-rich fibrin in the management of chronic nonhealing ulcers of the lower limb","volume":"14","author":"Singampalli Z","year":"2022","unstructured":"Singampalli Z, Rajan YRD, Hemanth Rathod R, et al. The efficacy of platelet-rich fibrin in the management of chronic nonhealing ulcers of the lower limb. Cureus 2022; 14(7): e26829. https:\/\/doi.org\/10.7759\/cureus.26829","journal-title":"Cureus"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ksujds.2013.09.001"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40267-023-01044-7"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/1110-1121.239205"},{"key":"e_1_3_6_8_2","volume-title":"Wound care treatment & management","author":"Daley BJ","year":"2020","unstructured":"Daley BJ. Wound care treatment & management. Medscape, 2020. https:\/\/www.medscape.com\/viewarticle\/194018_3 (Accessed 20 Mar. 2025)."},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_119_19"},{"key":"e_1_3_6_10_2","first-page":"e14","article-title":"Beyond wet-to-dry: a rational approach to treating chronic wounds","volume":"9","author":"Lee JC","year":"2009","unstructured":"Lee JC, Kandula S, Sherber NS. Beyond wet-to-dry: a rational approach to treating chronic wounds. 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