{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:46:25Z","timestamp":1777916785386,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse and compare the prevalence of comorbidities associated with lipedema in Spanish women with that in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted using an anonymous online questionnaire distributed among lipedema patient associations in Spain. Sociodemographic variables, clinical aspects, and comorbidities were collected. These were then compared with data from the 2023 National Health Survey, which represents the general Spanish population. The prevalence of each pathology was compared using odds ratios (OR) with 95% confidence intervals. Age-group contributions were assessed using standardised residuals from expected\/observed contingency tables, considering absolute values &gt;1.96 (95% confidence) to be significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1001 responses were obtained, with a mean age of 44.2\u00a0years. The most prevalent comorbidities were vitamin D deficiency (63.4%), lower limb venous insufficiency (47.2%), and migraine (43.1%). Compared to the general female population in Spain, patients with lipedema were more likely to suffer from venous insufficiency (OR= 5.05; 95% CI: 4.3\u20135.8), urinary incontinence (OR= 4.93; 95% CI: 4.1\u20135.8), migraine (OR= 3.9; 95% CI: 3.4\u20134.5), thyroid disease (OR= 2.21; 95% CI: 1.8\u20132.6), and asthma (OR= 2.09; 95% CI: 1.7\u20132.5). However, the probability of hypertension (OR= 0.38; 95% CI: 0.2\u20130.4) and diabetes (OR= 0.36; 95% CI: 0.2\u20130.6) was significantly lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Spanish women with lipedema have a higher prevalence of certain pathologies that should be considered in their medical care. Understanding these relationships is crucial to improving the detection and treatment of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555261435120","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:08:49Z","timestamp":1774548529000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of comorbidities associated with lipedema. A comparative study with the general population"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-9701","authenticated-orcid":false,"given":"Elena","family":"Vaquero-Ramiro","sequence":"first","affiliation":[{"name":"Hospital Universitario de Cuenca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-1461","authenticated-orcid":false,"given":"Ana-Bel\u00e9n","family":"Puentes-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Toledo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-0666","authenticated-orcid":false,"given":"Antonio","family":"Morandeira-Rivas","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario Mancha Centro, Alc\u00e1zar de San Juan, Spain"},{"name":"Instituto de Investigaciones Sanitarias de Castilla -La Mancha (IDISCAM), Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-1334","authenticated-orcid":false,"given":"Laura","family":"Mill\u00e1n-Casas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Mancha Centro"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda-Bascones","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Toledo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2023.0062"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-8111.2012.00045.x"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13953"},{"issue":"2","key":"e_1_3_7_5_2","first-page":"108","article-title":"Diagnosis and treatment of lipedema in Spain. Results of an online survey","volume":"56","author":"Vaquero-Ramiro E","year":"2022","unstructured":"Vaquero-Ramiro E, Guti\u00e9rrez Retortillo M, Goiri Noguera D, et al. Diagnosis and treatment of lipedema in Spain. Results of an online survey. Rehabilitacion 2022; 56(2): 108\u2013115. https:\/\/doi.org\/10.1016\/j.rh.2020.12.001","journal-title":"Rehabilitacion"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1223264"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111720"},{"key":"e_1_3_7_8_2","first-page":"17","volume-title":"Lipedema, mitos y realidades","author":"Puentes-Guti\u00e9rrez AB","year":"2024","unstructured":"Puentes-Guti\u00e9rrez AB, Garc\u00eda-Bascones M, Vaquero-Ramiro E, et al. Lipedema. Propuesta de un consenso de protocolo de evaluaci\u00f3n en consulta. En: Mill\u00e1n-Casas L. In: Garc\u00eda-Bascones M, Puentes-Guti\u00e9rrez AB, Vaquero-Ramiro E (eds). Lipedema, mitos y realidades. Publicaci\u00f3n Independiente, 2024, pp. 17\u201333."},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15182"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-68232-z"},{"key":"e_1_3_7_11_2","unstructured":"Encuesta de estado de salud. Instituto Nacional de Estad\u00edstica. 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