{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:18:11Z","timestamp":1787663891370,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deep vein thrombosis (DVT) is associated with inflammatory response that may contribute to incomplete venous recanalization and post-thrombotic syndrome (PTS). Diosmin, a venoactive flavonoid, may provide additional benefit when combined with standard anticoagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether adjunctive diosmin therapy reduces inflammation, improves recanalization, enhances quality of life, and decreases PTS severity in acute DVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study analyzed 612 patients with acute proximal DVT receiving anticoagulation alone (control,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 298) or anticoagulation plus diosmin 600\u00a0mg daily (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 314). Propensity score matching (1:1) yielded 230 pairs. C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and erythrocyte sedimentation rate (ESR) were assessed at baseline and day 30. Recanalization was evaluated by duplex ultrasound at 3 and 12\u00a0months. Quality of life was measured using VEINES-QOL, and PTS was assessed using the Villalta scale at 12\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The diosmin group showed greater reductions in CRP (\u221213.9 vs \u221211.8\u00a0mg\/L;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.038), NLR (\u22121.72 vs \u22121.43;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.019), and ESR (\u221217.2 vs \u221214.1\u00a0mm\/hr;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.031) at day 30. Complete recanalization rates were higher with diosmin at 12\u00a0months (91.3% vs 76.5%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). VEINES-QOL scores were better in the diosmin group at 12\u00a0months (71.8 \u00b1 13.2 vs 66.9 \u00b1 12.6; p = 0.024). While overall PTS incidence was similar (14.9% vs 16.3%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.72), moderate-to-severe PTS was less frequent with diosmin among PTS patients (21% vs 40%; Fisher\u2019s exact\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.062), suggesting a trend that requires confirmation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive diosmin was associated with greater inflammatory marker reductions, improved recanalization, and better quality of life. A trend toward reduced PTS severity was observed but should be interpreted cautiously given the small number of events. Prospective randomized trials are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555261446151","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:04:16Z","timestamp":1777122256000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-inflammatory effects of diosmin as adjunctive therapy in acute deep vein thrombosis: Impact on venous recanalization, quality of life and post-thrombotic syndrome"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-3522","authenticated-orcid":false,"given":"Dragan","family":"Nikoli\u0107","sequence":"first","affiliation":[{"name":"University Clinical Center of Vojvodina"},{"name":"University of Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janko","family":"Pasternak","sequence":"additional","affiliation":[{"name":"University Clinical Center of Vojvodina"},{"name":"University of Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Manojlovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center of Vojvodina"},{"name":"University of Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavko","family":"Budinski","sequence":"additional","affiliation":[{"name":"University Clinical Center of Vojvodina"},{"name":"University of Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Basta Nikoli\u0107","sequence":"additional","affiliation":[{"name":"University of Novi Sad"},{"name":"University Clinical Center of Vojvodina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Batini\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center of Vojvodina"},{"name":"University of Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.83"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304488"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-10-200811180-00004"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-1-199607010-00001"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13569"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121746"},{"key":"e_1_3_9_8_2","first-page":"306","article-title":"The role of inflammation in venous thromboembolism and the link between arterial and venous thrombosis","volume":"26","author":"Poredos P","year":"2007","unstructured":"Poredos P, Jezovnik MK. 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