{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:04:01Z","timestamp":1789448641510,"version":"build-2803163510"},"reference-count":13,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Phlebology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate longitudinal changes in dermal tissue stiffness measured by shear wave elastography (SWE) following radiofrequency ablation (RFA) of the great saphenous vein (GSV) and to examine the relationship between tissue-level and clinical recovery in chronic venous insufficiency (CVI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled 47 patients (55 extremities, including 8 bilateral cases) who underwent endovenous RFA for grade 4 GSV reflux between May and December 2022. SWE measurements were obtained preoperatively and at 3 and 12 months using a standardized protocol (Canon Aplio 500, lateral calf at a fixed anatomical reference). Longitudinal changes were analyzed using generalized estimating equations (GEE) on log-transformed values with robust standard errors. Spearman correlations between SWE and Venous Clinical Severity Score (VCSS) were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean SWE values were 19.13 \u00b1 9.81\u00a0kPa preoperatively, 18.62 \u00b1 10.10\u00a0kPa at 3 months (Holm-adjusted\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.669), and 11.30 \u00b1 6.62\u00a0kPa at 12 months (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). VCSS decreased from 4.04 \u00b1 1.60 to 0.78 \u00b1 0.74 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). VCSS and SWE were moderately associated at 12 months (\u03c1 = 0.499, adjusted\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), whereas their changes were not significantly associated (\u03c1 = 0.125, 95% CI \u22120.148 to 0.380;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.37).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results enhance the current literature by indicating that SWE demonstrated a delayed decrease in dermal stiffness after radiofrequency ablation and may provide complementary quantitative information on tissue-level changes not assessed by Doppler ultrasonography. Although not yet suitable for standard clinical use, SWE shows potential as an additional follow-up tool in chronic venous insufficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02683555261481211","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:54:53Z","timestamp":1787554493000},"page":"825-834","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Shear wave elastography of dermal stiffness after radiofrequency ablation for great saphenous vein reflux: A 12-month prospective study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-1817","authenticated-orcid":false,"given":"Cigdem","family":"Tel Ustunisik","sequence":"first","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan Onur","family":"Balkanay","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berk","family":"Arapi","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Yagci","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savas","family":"Cidem","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet U\u011furcan","family":"Turhan","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Department, Haseki Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vefa","family":"Salt","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauf","family":"Hamid","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat Nail","family":"Omeroglu","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Goksedef","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesur","family":"Samanc\u0131","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2004.05.015"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.53.3.149"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2023.08.011"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.126547"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1335375"},{"key":"e_1_3_7_7_2","first-page":"53","article-title":"Shear wave elastography combined with serological markers for the early detection of fibrosis in chronic venous disorders: a prospective study","volume":"40","author":"Lv D","year":"2025","unstructured":"Lv D, Yang X, Mao X, et al. Shear wave elastography combined with serological markers for the early detection of fibrosis in chronic venous disorders: a prospective study. Phlebology 2025; 40: 53\u201362.","journal-title":"Phlebology"},{"key":"e_1_3_7_8_2","first-page":"229","article-title":"Quantitative assessment of tissue stiffness with shear wave elastography in chronic venous insufficiency","volume":"29","author":"Durmaz MS","year":"2021","unstructured":"Durmaz MS. Quantitative assessment of tissue stiffness with shear wave elastography in chronic venous insufficiency. Vascular 2021; 29: 229\u2013236.","journal-title":"Vascular"},{"key":"e_1_3_7_9_2","first-page":"64","article-title":"Tissue stiffness assessment with ultrasound elastography in chronic venous disease","volume":"37","author":"Baltacioglu F","year":"2021","unstructured":"Baltacioglu F, Acar BG. Tissue stiffness assessment with ultrasound elastography in chronic venous disease. Ultrasound Q 2021; 37: 64\u201369.","journal-title":"Ultrasound Q"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.14366\/usg.18039"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13448"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S564514"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0000000000000356"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2025.1578436"}],"container-title":["Phlebology: The Journal of Venous Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02683555261481211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02683555261481211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02683555261481211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:48:41Z","timestamp":1789447721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02683555261481211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,23]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/02683555261481211"],"URL":"https:\/\/doi.org\/10.1177\/02683555261481211","relation":{},"ISSN":["0268-3555","1758-1125"],"issn-type":[{"value":"0268-3555","type":"print"},{"value":"1758-1125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,23]]}}}