{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:37:07Z","timestamp":1776944227290,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T00:00:00Z","timestamp":1274140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p> Objective: To evaluate the effect of acoustic cueing using metronomes on the quality of life of people with moderate to severe Parkinson\u2019s disease. <\/jats:p><jats:p> Study design: Pragmatic, single-blind, randomized cross-over trial. <\/jats:p><jats:p> Participants: Forty-two people aged 50\u201485 years, in Hoehn and Yahr stage II\u2014IV and on stable medication. Eight were lost to follow-up. <\/jats:p><jats:p> Intervention: Participants were randomized using concealed allocation to either an early group (n = 21) to receive an electronic metronome without therapy but limited support (5\u201410 minutes instruction and on-demand telephone assistance) for four weeks, or a late group (n = 21) to receive the same intervention at 10 weeks. In both groups the beat frequency was initially set to be comfortable for walking. <\/jats:p><jats:p> Outcomes measures: Primary and secondary outcomes were measured at baseline, 4, 10 and 14 weeks using the Parkinson\u2019s Disease Questionnaire 39 (PDQ-39), the Short Form 36 version 2 (SF-36 version 2) and a falls diary. <\/jats:p><jats:p> Results: There were positive effects in six domains of the SF-36 version 2 and eight domains of the PDQ-39, although only one mean difference was clinically important: the role limitation (emotional) domain of SF-36 version 2 (a mean difference of 3.77, 95% confidence interval (CI), \u20142.68 to 10.22), a secondary outcome. None of these changes were statistically significant. There were no statistically significant differences in falls rates over the study period. Ten participants (24%) wanted to continue with their metronomes at the end of the study. <\/jats:p><jats:p> Conclusion: To demonstrate metronomes are beneficial on the role limitation domain of the SF-36 version 2 in people with moderate to severe Parkinson\u2019s disease a sample size of 600 would be required. <\/jats:p>","DOI":"10.1177\/0269215509360646","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T00:35:26Z","timestamp":1274229326000},"page":"523-532","source":"Crossref","is-referenced-by-count":19,"title":["Do metronomes improve the quality of life in people with Parkinson\u2019s disease? 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