{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:59:48Z","timestamp":1789156788736,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Objectives: To estimate the effects of low level laser therapy in combination with a programme of exercises on pain, functionality, range of motion, muscular strength and quality of life in patients with osteoarthritis of the knee.<\/jats:p>\n                  <jats:p>Design: A randomized double-blind placebo-controlled trial with sequential allocation of patients to different treatment groups.<\/jats:p>\n                  <jats:p>Setting: Special Rehabilitation Services.<\/jats:p>\n                  <jats:p>Subjects: Forty participants with knee osteoarthritis, 2\u20134 osteoarthritis degree, aged between 50 and 75 years and both genders.<\/jats:p>\n                  <jats:p>Intervention: Participants were randomized into one of two groups: the laser group (low level laser therapy dose of 3\u2009J and exercises) or placebo group (placebo laser and exercises).<\/jats:p>\n                  <jats:p>Main measures: Pain was assessed using a visual analogue scale (VAS), functionality using the Lequesne questionnaire, range of motion with a universal goniometer, muscular strength using a dynamometer, and activity using the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) questionnaire at three time points: (T1) baseline, (T2) after the end of laser therapy (three weeks) and (T3) the end of the exercises (11 weeks).<\/jats:p>\n                  <jats:p>Results: When comparing groups, significant differences in the activity were also found ( P\u2009=\u20090.03). No other significant differences ( P\u2009&gt;\u20090.05) were observed in other variables. In intragroup analysis, participants in the laser group had significant improvement, relative to baseline, on pain ( P\u2009=\u20090.001), range of motion ( P\u2009=\u20090.01), functionality ( P\u2009=\u20090.001) and activity ( P\u2009&lt;\u20090.001). No significant improvement was seen in the placebo group.<\/jats:p>\n                  <jats:p>Conclusion: Our findings suggest that low level laser therapy when associated with exercises is effective in yielding pain relief, function and activity on patients with osteoarthritis of the knees.<\/jats:p>","DOI":"10.1177\/0269215511425962","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T23:52:10Z","timestamp":1323906730000},"page":"523-533","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":99,"title":["Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study"],"prefix":"10.1177","volume":"26","author":[{"given":"Patr\u00edcia Pereira","family":"Alfredo","sequence":"first","affiliation":[{"name":"Department of Speech Therapy, Physical Therapy and Occupational Therapy, School of Medicine, S\u00e3o Paulo University, S\u00e3o 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