{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:22:58Z","timestamp":1777533778987,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the long-term effects of low-level laser therapy (LLLT), in combination with strengthening exercises in patients with osteoarthritis of the knee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Follow-up results at three and six months in a previously published randomized, double-blind, placebo-controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Specialist Rehabilitation Services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects:<\/jats:title>\n                    <jats:p>Forty participants of both genders, aged 50\u201375\u2009years with knee osteoarthritis grade 2\u20134 on Kellgren\u2013Lawrence scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>The LLLT group received 10 LLLT treatments with invisible infrared laser (904\u2009nm, 3\u2009Joules\/point) over three\u2009weeks followed by an eight-week supervised strengthening exercise program. The placebo LLLT group received identical treatment, but the infrared laser output was disabled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main measures:<\/jats:title>\n                    <jats:p>Pain on a visual analogue scale, paracetamol consumption, and osteoarthritis severity measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Lequesne Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The new data obtained during the follow-up period showed that all outcomes remained stable and there were no significant differences between the groups at three and six\u2009months. However, daily consumption of rescue analgesics (paracetamol) was significantly lower in the LLLT group throughout the follow-up period, ending at a group difference of 0.45 vs. 3.40 units ( P\u2009&lt;\u20090.001) at six\u2009months follow-up. We conclude that within the limitations of this small study, the previously reported improvement after LLLT plus exercise was maintained for a period of six\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We find that the immediate post-intervention improvements from LLLT plus strengthening exercises were maintained for six\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269215517723162","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T07:41:32Z","timestamp":1501832492000},"page":"173-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Long-term results of a randomized, controlled, double-blind study of low-level laser therapy before exercises in knee osteoarthritis: laser and exercises in knee osteoarthritis"],"prefix":"10.1177","volume":"32","author":[{"given":"Patr\u00edcia Pereira","family":"Alfredo","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Speech Therapy and Occupational Therapy, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Magnus","family":"Bjordal","sequence":"additional","affiliation":[{"name":"Physiotherapy Research Group, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Washington Steagall","family":"Junior","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Odontology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo \u00c1lvaro Brand\u00e3o","family":"Lopes-Martins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Technological Research Center - NPT, University of Mogi das Cruzes-UMC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B","family":"Stausholm","sequence":"additional","affiliation":[{"name":"Physiotherapy Research Group, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Aparecida","family":"Casarotto","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Speech Therapy and Occupational Therapy, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lia Pasqual","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Speech Therapy and Occupational Therapy, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Joensen","sequence":"additional","affiliation":[{"name":"Physiotherapy Research Group, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"bibr1-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.14.1576"},{"key":"bibr2-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.08.002"},{"key":"bibr3-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"bibr4-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2012.3240"},{"key":"bibr5-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2297"},{"key":"bibr6-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1177\/0269215511425962"},{"key":"bibr7-0269215517723162","first-page":"155","volume":"26","author":"Bulow PM","year":"1994","journal-title":"Scand J Rehabil Med"},{"key":"bibr8-0269215517723162","first-page":"254","volume":"134","author":"Tascioglu F","year":"2004","journal-title":"Swiss Med Wkly"},{"key":"bibr9-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-8-51"},{"key":"bibr10-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10236"},{"key":"bibr11-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-016-0605-9"},{"key":"bibr12-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167076"},{"key":"bibr13-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9406(05)60030-2"},{"key":"bibr14-0269215517723162","first-page":"2384","volume":"32","author":"Niethard FU","year":"2005","journal-title":"J Rheumatol"},{"key":"bibr15-0269215517723162","first-page":"83","volume":"15","author":"Ulugol A","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"bibr16-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0906-1"},{"key":"bibr17-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1002\/art.21357"},{"key":"bibr18-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1600-x"},{"key":"bibr19-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.12.128004"},{"key":"bibr20-0269215517723162","first-page":"297","volume":"32","author":"Nambi GS","year":"2016","journal-title":"Lasers Med Sci"},{"key":"bibr21-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.01.003"},{"key":"bibr22-0269215517723162","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.04.005"}],"container-title":["Clinical Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269215517723162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269215517723162","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269215517723162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:53:41Z","timestamp":1777395221000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269215517723162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,4]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1177\/0269215517723162"],"URL":"https:\/\/doi.org\/10.1177\/0269215517723162","relation":{},"ISSN":["0269-2155","1477-0873"],"issn-type":[{"value":"0269-2155","type":"print"},{"value":"1477-0873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,4]]}}}