{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:07:28Z","timestamp":1790950048194,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To collect data to estimate the sample size of a definitive randomized controlled trial to evaluate the effects of Melodic Intonation Therapy in post-stroke nonfluent aphasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A randomized, crossover, interventional pilot trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Departments of Neurology and Rehabilitation from a university general hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Stroke survivors with post-stroke nonfluent aphasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Patients randomized to group 1 had treatment with Melodic Intonation Therapy first (12 sessions over six\u2009weeks) followed by no treatment; the patients in group 2 started active treatment between three and six\u2009months after their inclusion in the study, serving as waiting list controls for the first phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main measures:<\/jats:title>\n                    <jats:p>The Communicative Activity Log (CAL) questionnaire and the Boston Diagnostic Aphasia Examination (BDAE) were evaluated at baseline, and at six and 12\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty patients were included. Four of the patients allocated to group 2 crossed over to group 1, receiving the treatment at first. Intention-to-treat analysis: after adjustment for baseline scores, the mean difference in the CAL evaluation from baseline in the treated group was 8.5 points (95% confidence interval (CI), 0.11\u201317.0; P\u2009=\u2009.043), with no significant change in any of the BDAE sections. Per-protocol analysis showed similar results with a clear treatment effect ( P\u2009=\u2009.043) on the CAL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Melodic Intonation Therapy might have a positive effect on the communication skills of stroke survivors with nonfluent aphasia as measured by the CAL questionnaire. A full-scale trial with at least 27 patients per group is necessary to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269215518791004","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T04:28:46Z","timestamp":1532924926000},"page":"44-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Melodic intonation therapy in post-stroke nonfluent aphasia: a randomized pilot trial"],"prefix":"10.1177","volume":"33","author":[{"given":"Ana M","family":"Haro-Mart\u00ednez","sequence":"first","affiliation":[{"name":"PhD Program, School of Medicine, Autonomous University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genny","family":"Lubrini","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Autonomous University of Madrid, Madrid, Spain"},{"name":"School of Health Sciences, Francisco de Vitoria University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Madero-Jarabo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, La Paz University Hospital, IdiPAZ Health Research Institute, Autonomous University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-1707","authenticated-orcid":false,"given":"Exuperio","family":"D\u00edez-Tejedor","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Autonomous University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-862X","authenticated-orcid":false,"given":"Blanca","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Autonomous University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"bibr1-0269215518791004","first-page":"CD000425","volume":"5","author":"Brady MC","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr2-0269215518791004","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490260074018"},{"key":"bibr3-0269215518791004","first-page":"221","volume-title":"Manual of aphasia and aphasia therapy","author":"Helm-Estabrooks A","year":"2004"},{"key":"bibr4-0269215518791004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04859.x"},{"key":"bibr5-0269215518791004","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00007"},{"key":"bibr6-0269215518791004","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.10.44"},{"key":"bibr7-0269215518791004","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00401"},{"key":"bibr8-0269215518791004","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00520"},{"key":"bibr9-0269215518791004","first-page":"641","volume":"26","author":"Ren da","year":"2014","journal-title":"Dist\u00farbios Comun"},{"key":"bibr10-0269215518791004","first-page":"311","volume":"22","author":"Van Eeckhout P","year":"1984","journal-title":"R\u00e9\u00e9ducation Orthophonique"},{"key":"bibr11-0269215518791004","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2017.1279731"},{"key":"bibr12-0269215518791004","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5239"},{"key":"bibr13-0269215518791004","first-page":"129","volume-title":"La Evaluaci\u00f3n de la Afasia y de Trastornos Relacionados","author":"Garc\u00eda-Albea J","year":"1986"},{"key":"bibr14-0269215518791004","first-page":"267","volume":"111","author":"Marrugat J","year":"1998","journal-title":"Med Clin"},{"key":"bibr15-0269215518791004","unstructured":"Marrugat J. 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