{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:59:54Z","timestamp":1787839194080,"version":"build-2784847793"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bayer Hemophilia Awards Program","award":["Caregiver Award 2016"],"award-info":[{"award-number":["Caregiver Award 2016"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effects of a manual therapy using fascial therapy on joint bleeding, joint pain and joint function in patients with hemophilic ankle arthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Hemophilia patient associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Randomized, controlled trial, multicenter and intention-to-treat analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>A total of 65 patients with hemophilic ankle arthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>The experimental group ( n\u2009=\u200933) received one fascial therapy session per week for three\u2009weeks. The control group ( n\u2009=\u200932) received no treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measure:<\/jats:title>\n                    <jats:p>The primary outcome was frequency of joint bleeding measured using self-reporting. Secondary outcomes were joint pain (under load-bearing and non-load-bearing conditions) measured using the visual analog scale; joint condition was measured using the Hemophilia Joint Health Score. Outcomes were measured at baseline, posttreatment and after five\u2009months of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Improvements in the frequency joint bleeding at T0, T1 and T2 were significantly higher in the experimental group (T0: mean (SD)\u2009=\u20091.56 (1.30); T1: mean (SD)\u2009=\u20090.00 (0.00); T2: mean (SD)\u2009=\u20090.27 (0.57)) compared to the control group (T0: mean (SD)\u2009=\u20091.70 (1.78); T1: mean (SD)\u2009=\u20090.05 (0.21); T2: mean (SD)\u2009=\u20090.58 (0.85)). Mean improvement of joint state after the study period was 1.74 points (\u00b11.66) for patients in the experimental group, while the control group exhibited a joint deterioration with 0.43 points (\u00b10.85). Ankle joint pain under load-bearing and non-load-bearing conditions improved in the experimental group with \u22121.72 (\u00b11.86) and \u22120.50 (\u00b11.39) points, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study showed that fascial therapy is favorable for patients with hemophilic ankle arthropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269215519879212","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T07:13:15Z","timestamp":1569568395000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of manual therapy in patients with hemophilia and ankle arthropathy: a randomized clinical trial"],"prefix":"10.1177","volume":"34","author":[{"given":"Elena","family":"Donoso-\u00dabeda","sequence":"first","affiliation":[{"name":"Optimus Osteopathy and Physiotherapy Clinic, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mero\u00f1o-Gallut","sequence":"additional","affiliation":[{"name":"T\u00fa. Bienestar 360\u00ba, Pysiotherapy and Medical Center, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"L\u00f3pez-Pina","sequence":"additional","affiliation":[{"name":"Department of Basic Psychology and Methodology, Faculty of Psychology, University of Murcia, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4276-6982","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Cuesta-Barriuso","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, European University of Madrid, Madrid, Spain"},{"name":"Royal Victoria Eugenia Foundation, Madrid, Spain"},{"name":"Fishemo CEE, Spanish Federation of Hemophilia, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"bibr1-0269215519879212","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12375"},{"key":"bibr2-0269215519879212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01876.x"},{"key":"bibr3-0269215519879212","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-683169"},{"key":"bibr4-0269215519879212","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-102202"},{"key":"bibr5-0269215519879212","volume-title":"Inducci\u00f3n miofascial. 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