{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:49:58Z","timestamp":1782388198983,"version":"3.54.5"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess if a higher dose of exercise training in exercise-based cardiac rehabilitation could affect improvements in aerobic capacity and muscle strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Assessor-blinded randomized controlled trial with 12-months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Aarhus University Hospital, Aarhus, Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects:<\/jats:title>\n                    <jats:p>A total of 164 cardiac patients referred to exercise-based cardiac rehabilitation were recruited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Patients were randomized to 1-hour exercise sessions either three times weekly for 12\u2009weeks (36 sessions, high-dose group) or twice weekly for 8\u2009weeks (16 sessions, low-dose group). The same standardized exercise and intensity protocol including aerobic and muscle strength training was used in all participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main measures:<\/jats:title>\n                    <jats:p>\n                      Primary outcome was changes in VO\n                      <jats:sub>2peak<\/jats:sub>\n                      . Secondary outcomes were changes in maximal workload, muscle strength and power. Measures were obtained at baseline, after termination of the rehabilitation programme and at follow-up after 6 and 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After the end of intervention, statistically significant between-group differences were seen in favour of the high-dose group in all outcomes: VO\n                      <jats:sub>2peak<\/jats:sub>\n                      2.6 (mL\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u2009min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) (95% confidence interval (CI): 0.4\u20134.8), maximal workload 0.3\u2009W\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      (95%CI: 0.02\u20130.5), isometric muscle strength 0.7\u2009N\u2009m\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      (95%CI: 0.1\u20131.2) and muscle power 0.3\u2009W\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      (95%CI: 0.04\u20130.6). After 12\u2009months, a significant between-group difference only persisted in VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and maximal workload.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      A higher dose of exercise training had a small effect on all outcomes at termination of intervention. A long-term effect persisted in VO\n                      <jats:sub>2peak<\/jats:sub>\n                      and maximal workload. Although the effect was small, it is an important finding because VO\n                      <jats:sub>2peak<\/jats:sub>\n                      is the most important predictor of all-cause mortality in cardiac patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269215519883411","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T05:51:02Z","timestamp":1571809862000},"page":"69-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A comparison of high versus low dose of exercise training in exercise-based cardiac rehabilitation: a randomized controlled trial with 12-months follow-up"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-9001","authenticated-orcid":false,"given":"Annemette Krintel","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Centre of Research in Rehabilitation (CORIR), Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-1391","authenticated-orcid":false,"given":"Lisa Gregersen","family":"Oestergaard","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Centre of Research in Rehabilitation (CORIR), Aarhus University Hospital, Aarhus, Denmark"},{"name":"Research Initiative of Activity Studies and Occupational Therapy, Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurits","family":"van Tulder","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Health Sciences, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sussie","family":"Laustsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, 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