{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:29:09Z","timestamp":1777534149996,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001254","name":"ipsen fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The aim of this study is to evaluate a novel composite measure of active range of motion (X\n                      <jats:sub>A<\/jats:sub>\n                      ) and determine whether this measure correlates with active function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Post hoc analysis of two randomized, placebo-controlled, double-blind studies with open-label extensions exploring changes in active function with abobotulinumtoxinA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Tertiary rehabilitation centers in Australia, Europe, and the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects:<\/jats:title>\n                    <jats:p>Adults with upper ( n\u2009=\u2009254) or lower ( n\u2009=\u2009345) limb spastic paresis following stroke or brain trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>AbobotulinumtoxinA (\u2a7d5 treatment cycles) in the upper or lower limb.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main measures:<\/jats:title>\n                    <jats:p>\n                      X\n                      <jats:sub>A<\/jats:sub>\n                      was used to calculate a novel composite measure (CX\n                      <jats:sub>A<\/jats:sub>\n                      ), defined as the sum of X\n                      <jats:sub>A<\/jats:sub>\n                      against elbow, wrist, and extrinsic finger flexors (upper limb) or soleus and gastrocnemius muscles (lower limb). Active function was assessed by the Modified Frenchay Scale and 10-m comfortable barefoot walking speed in the upper limb and lower limb, respectively. Correlations between CX\n                      <jats:sub>A<\/jats:sub>\n                      and active function at Weeks 4 and 12 of open-label cycles were explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CX\n                      <jats:sub>A<\/jats:sub>\n                      and active function were moderately correlated in the upper limb ( P\u2009&lt;\u20090.0001\u20130.0004, r\u2009=\u20090.476\u20130.636) and weakly correlated in the lower limb ( P\u2009&lt;\u20090.0001\u20130.0284, r\u2009=\u20090.186\u20130.285) at Weeks 4 and 12 of each open-label cycle. Changes in CX\n                      <jats:sub>A<\/jats:sub>\n                      and active function were weakly correlated only in the upper limb (Cycle 2 Week 12, P\u2009=\u20090.0160, r\u2009=\u20090.213; Cycle 3 Week 4, P\u2009=\u20090.0031, r\u2009=\u20090.296). Across cycles, CX\n                      <jats:sub>A<\/jats:sub>\n                      improvements peaked at Week 4, while functional improvements peaked at Week 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      CX\n                      <jats:sub>A<\/jats:sub>\n                      is a valid measure for functional impairments in spastic paresis. CX\n                      <jats:sub>A<\/jats:sub>\n                      improvements following abobotulinumtoxinA injection correlated with and preceded active functional improvements.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269215520911970","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:39:12Z","timestamp":1587947952000},"page":"803-811","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Composite active range of motion (CX\n                    <sub>A<\/sub>\n                    ) and relationship with active function in upper and lower limb spastic paresis"],"prefix":"10.1177","volume":"34","author":[{"given":"Nicolas","family":"Bayle","sequence":"first","affiliation":[{"name":"EA 7377 BIOTN, Service de R\u00e9\u00e9ducation Neurolocomotrice, Universit\u00e9 Paris-Est Cr\u00e9teil, Hospital Albert Chenevier-Henri Mondor, 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