{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:31:39Z","timestamp":1777534299575,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022031","name":"Tavistock Trust for Aphasia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022031","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["12\/21\/01"],"award-info":[{"award-number":["12\/21\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the cost-effectiveness of self-managed computerised word finding therapy as an add-on to usual care for people with aphasia post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cost-effectiveness modelling over a life-time period, taking a UK National Health Service (NHS) and personal social service perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Based on the Big CACTUS randomised controlled trial, conducted in 21 UK NHS speech and language therapy departments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Big CACTUS included 278 people with long-standing aphasia post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Computerised word finding therapy plus usual care; usual care alone; usual care plus attention control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main measures:<\/jats:title>\n                    <jats:p>Incremental cost-effectiveness ratios (ICER) were calculated, comparing the cost per quality adjusted life year (QALY) gained for each intervention. Credible intervals (CrI) for costs and QALYs, and probabilities of cost-effectiveness, were obtained using probabilistic sensitivity analysis. Subgroup and scenario analyses investigated cost-effectiveness in different subsets of the population, and the sensitivity of results to key model inputs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Adding computerised word finding therapy to usual care had an ICER of \u00a342,686\u2009per QALY gained compared with usual care alone (incremental QALY gain: 0.02\u2009per patient (95% CrI: \u22120.05 to 0.10); incremental costs: \u00a3732.73\u2009per patient (95% CrI: \u00a3674.23 to \u00a3798.05)). ICERs for subgroups with mild or moderate word finding difficulties were \u00a322,371 and \u00a321,262\u2009per QALY gained respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Computerised word finding therapy represents a low cost add-on to usual care, but QALY gains and estimates of cost-effectiveness are uncertain. Computerised therapy is more likely to be cost-effective for people with mild or moderate, as opposed to severe, word finding difficulties.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269215520975348","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:41:57Z","timestamp":1606264917000},"page":"703-717","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Self-managed, computerised word finding therapy as an add-on to usual care for chronic aphasia post-stroke: An economic evaluation"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-5585","authenticated-orcid":false,"given":"Nicholas R","family":"Latimer","sequence":"first","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Bhadhuri","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abualbishr","family":"Alshreef","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Palmer","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Cross","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"},{"name":"Sheffield Clinical Trials Research Unit, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munyaradzi","family":"Dimairo","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"},{"name":"Sheffield Clinical Trials Research Unit, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Julious","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Cooper","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"},{"name":"Sheffield Clinical Trials Research Unit, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Enderby","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-7021","authenticated-orcid":false,"given":"Marian C","family":"Brady","sequence":"additional","affiliation":[{"name":"NMAHP Research Unit, Glasgow Caledonian University, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Bowen","sequence":"additional","affiliation":[{"name":"Division of Neuroscience & Experimental Psychology, FBMH, University of Manchester, MAHSC, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Bradley","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"},{"name":"Sheffield Clinical Trials Research Unit, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Harrison","sequence":"additional","affiliation":[{"name":"ScHARR, The University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"bibr1-0269215520975348","unstructured":"Stroke Association. 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