{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:47:29Z","timestamp":1792547249222,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess whether the treatment with intermittent pneumatic compression plus multilayer bandages is not inferior to classical trimodal therapy with manual lymphatic drainage in the decongestive lymphedema treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Randomized, non-inferiority, controlled study to compare the efficacy of three physical therapies\u2019 regimens in the Decongestive Lymphatic Therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>194 lymphedema patients, stage II\u2013III with excess volume &gt; 10% were stratified within upper and lower limb and then randomized to one of the three treatment groups. Baseline characteristics were comparable between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>all patients were prescribed 20 sessions of the following regimens: Group A (control group): manual lymphatic drainage + Intermittent Pneumatic Compression + Bandages; Group B: pneumatic lymphatic drainage + Intermittent Pneumatic Compression + Bandages; and Group C: only Intermittent Pneumatic Compression + Bandages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>End-point:<\/jats:title>\n                    <jats:p>Percentage reduction in excess volume (PREV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All patients improved after treatment. Global mean of PREV was 63.9%, without significant differences between the groups. The lower confidence interval of the mean difference in PREV between group B and group A, and between group C and group A were below 15%, thus meeting the non-inferiority criterion. Most frequent adverse events were discomfort and lymphangitis, without differences between groups. A greater baseline edema, an upper-limb lymphedema and a history of dermatolymphangitis were independent predictive factors of worse response in the multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Decongestive lymphatic therapy performed only with intermittent pneumatic compression plus bandages is not inferior to the traditional trimodal therapy with manual lymphatic drainage. This approach did not increase adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692155211032651","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T07:14:55Z","timestamp":1631517295000},"page":"1743-1756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Physical therapies in the decongestive treatment of lymphedema: A randomized, non-inferiority controlled study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-037X","authenticated-orcid":false,"given":"Isabel","family":"Forner-Cordero","sequence":"first","affiliation":[{"name":"Lymphedema Unit, Rehabilitation Department, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mu\u00f1oz-Langa","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Arnau de Vilanova, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Mar\u00eda","family":"DeMiguel-Jimeno","sequence":"additional","affiliation":[{"name":"Rehabilitation Unit, Hospital San Pedro, Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Rel-Monz\u00f3","sequence":"additional","affiliation":[{"name":"Phyisiotherapy Service, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"bibr1-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4731"},{"issue":"6","key":"bibr2-02692155211032651","first-page":"541","volume":"32","author":"Lee BB","year":"2013","journal-title":"Int Angiol"},{"key":"bibr3-02692155211032651","unstructured":"The Swedish Council on Technology Assessment in Health Care. Manual lymph drainage combined with compression therapy for arm lymphedema following breast cancer treatment. SBU alert report no 2005-04. In: SBU alert [database online]. Stockhom: SBU, 2005. https:\/\/www.sbu.se\/en\/publications\/sbu-assesses\/manual-lymph-drainage-combined-with-compression-therapy-for-arm-lymphedema-following-breast-cancer-treatment\/"},{"key":"bibr4-02692155211032651","volume-title":"Best practice for the management of lymphoedema. International consensus","author":"Lymphoedema Framework","year":"2006"},{"issue":"1","key":"bibr5-02692155211032651","first-page":"3","volume":"53","author":"Executive Committee of the International Society of Lymphology","year":"2020","journal-title":"Lymphology"},{"key":"bibr6-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1188\/14.CJON.S3.68-79"},{"key":"bibr7-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2012.05.003"},{"key":"bibr8-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14442"},{"key":"bibr9-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003140.pub2"},{"key":"bibr10-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000246"},{"key":"bibr11-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9297-6"},{"key":"bibr12-02692155211032651","first-page":"60","volume-title":"Therapy","author":"Kurz I","year":"1989","edition":"2"},{"key":"bibr13-02692155211032651","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20150412"},{"key":"bibr14-02692155211032651","volume":"5","author":"Ezzo J","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr15-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023192"},{"key":"bibr16-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzaa087"},{"issue":"50","key":"bibr17-02692155211032651","first-page":"4","volume":"17","author":"Belgrado JP","year":"2007","journal-title":"Eur J Lymphol Relat Probl"},{"key":"bibr18-02692155211032651","doi-asserted-by":"crossref","unstructured":"Forner-Cordero I, Belgrado JP. Chapter 58. Sequential intermittent pneumatic compression (SIPC): rationale? How much it can be incorporated to compression therapy? In: Lee BB, Gloviczki P, Blei F (eds) Vascular malformations: advances and controversies in contemporary management. Boca Raton: CRC Press, 2020. https:\/\/bookshelf.vitalsource.com\/#\/books\/9781000731880\/p:261-264","DOI":"10.1201\/9780367255343-58"},{"key":"bibr19-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0034"},{"key":"bibr20-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10976"},{"key":"bibr21-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1177\/0269215519888792"},{"key":"bibr22-02692155211032651","first-page":"2","volume-title":"European Wound Management Association","author":"Partsch H.","year":"2003"},{"issue":"3","key":"bibr23-02692155211032651","first-page":"193","volume":"27","author":"Partsch H","year":"2008","journal-title":"Int Angiol"},{"key":"bibr24-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2018.0005"},{"issue":"5","key":"bibr25-02692155211032651","first-page":"442","volume":"29","author":"Partsch H","year":"2010","journal-title":"Int Angiol"},{"key":"bibr26-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0778-9"},{"key":"bibr27-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.01.001"},{"key":"bibr28-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1080\/028418600750013186"},{"issue":"2","key":"bibr29-02692155211032651","first-page":"56","volume":"31","author":"Johansson K","year":"1998","journal-title":"Lymphology"},{"key":"bibr30-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000032978.67677.9f"},{"key":"bibr31-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.06.017"},{"issue":"2","key":"bibr32-02692155211032651","first-page":"80","volume":"41","author":"Yamamoto T","year":"2008","journal-title":"Lymphology"},{"key":"bibr33-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0001"},{"key":"bibr34-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0090"},{"key":"bibr35-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1795-5"},{"issue":"47","key":"bibr36-02692155211032651","first-page":"17","volume":"16","author":"Belgrado JP","year":"2006","journal-title":"Eur J Lymphol Relat Probl"},{"key":"bibr37-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9021-y"},{"key":"bibr38-02692155211032651","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzaa012"}],"container-title":["Clinical Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692155211032651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02692155211032651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692155211032651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:55:23Z","timestamp":1777395323000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02692155211032651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/02692155211032651"],"URL":"https:\/\/doi.org\/10.1177\/02692155211032651","relation":{},"ISSN":["0269-2155","1477-0873"],"issn-type":[{"value":"0269-2155","type":"print"},{"value":"1477-0873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]}}}