{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:11:44Z","timestamp":1777533104360,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review aimed to assess the safety and effectiveness of acute intermittent hypoxia to improve motor outcomes in individuals with incomplete spinal cord injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data source<\/jats:title>\n                    <jats:p>Pubmed, Embase, Scopus, and Cochrane Library databases were searched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Review methods<\/jats:title>\n                    <jats:p>We only included randomized controlled trials (published up to September 2025) that met the following criteria: participants were adults with incomplete spinal cord injury; the intervention involved acute intermittent hypoxia with or without motor training; the control group received sham acute intermittent hypoxia with or without motor training; outcomes included motor functions. Risk of bias was evaluated using RoB2 tool. Risk and mean differences were computed, with a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine randomized controlled trials (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009114) were included. Overall risk of bias was with some concerns. The review indicates that acute intermittent hypoxia is safe and has good treatment adherence, with low drop-out rates for acute intermittent hypoxia alone (RD\u2009=\u20090.08; 95% confidence interval (CI): \u22120.11\u20130.26;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200966) or with gait training (RD\u2009=\u20090.04; 95% CI: \u22120.11\u20130.18;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200957). Acute intermittent hypoxia was found to have beneficial effects on walking speed (MD\u2009=\u20095.97; 95% CI: 1.4\u201310.54;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200953), endurance (MD\u2009=\u200939.39; 95% CI: 1.92\u201376.86;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200950%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200954), muscle strength, and manual dexterity. However, no significant effects were observed on balance functions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute intermittent hypoxia may be a promising adjunctive therapy to enhance motor function in individuals with incomplete spinal cord injury. Further research with standardized protocols and larger sample sizes is needed to optimize its use in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692155251388395","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:41:41Z","timestamp":1761046901000},"page":"11-29","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of acute intermittent hypoxia on enhancing motor functions in adults with incomplete spinal cord injury: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"40","author":[{"given":"Emmanuel Segnon","family":"Sogbossi","sequence":"first","affiliation":[{"name":"Laval University"},{"name":"Universit\u00e9 Laval"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastien","family":"Bouffanet","sequence":"additional","affiliation":[{"name":"UCLouvain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Pincede","sequence":"additional","affiliation":[{"name":"UCLouvain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Ribon-Demars","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-5693","authenticated-orcid":false,"given":"Gauthier","family":"Everard","sequence":"additional","affiliation":[{"name":"Laval University"},{"name":"Universit\u00e9 Laval"},{"name":"UCLouvain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00287-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2017.11.3.412"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.82"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4577"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0034-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113751"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.060"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968316680494"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40141-020-00270-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113735"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000437416.34298.43"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004596"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4478"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.09.114"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-025-08012-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2025.112211"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.12968\/ijtr.2023.0091"},{"key":"e_1_3_3_19_2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. 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