{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T21:48:12Z","timestamp":1782078492747,"version":"3.54.5"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nutricia DANONE"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Rehabil"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between increased energy and protein intake through oral nutritional supplements and mortality and hospital admissions in older hip fracture patients at nutritional risk, using a preplanned secondary analysis of a randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Department of Orthopaedic Surgery, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Hip fracture patients aged \u226565 at nutritional risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Participants were randomised to receive two cans daily of high-energy, high-protein oral nutritional supplements enriched with vitamin D and omega-3 fatty acids for 12 weeks after discharge or standard care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Measures<\/jats:title>\n                    <jats:p>All-cause mortality and hospital admissions during a pre-planned 38-week follow-up after discharge, including time to first admission and length of hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All-cause mortality was low, with no difference between intervention and control groups 2 (3%) versus 3 (5%). During follow-up, 31% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200919) of intervention participants was admitted to hospital compared with 47% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200929) in the control group. The difference approached significance in the intention-to-treat analysis (Risk ratio 0.72, 95% CI 0.51\u20131.03,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.075) and was statistically significant in the per-protocol analysis (18% vs. 44%; Risk ratio 0.69, 95% CI 0.52\u20130.92,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.019). No significant differences were observed in admissions frequency, length of hospital stay, or time to first admission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-discharge oral nutritional supplementation was associated with a trend towards fewer hospital admission, with the strongest effect among adherent participants. No significant effects were observed in mortality, admission frequency, length of hospital stay or time to admission.<\/jats:p>\n                    <jats:p>ClinicalTrials.gov: NCT05556876. Date of registration: 2022-09-23.<\/jats:p>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05556876\">https:\/\/clinicaltrials.gov\/study\/NCT05556876<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692155261459227","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:54:45Z","timestamp":1781600085000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of oral nutritional supplements on mortality and hospital admissions in older hip fracture patients at nutritional risk: secondary analysis of a randomised controlled trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1508-3696","authenticated-orcid":false,"given":"Alberte","family":"Jensen","sequence":"first","affiliation":[{"name":"The Dietitians and Nutritional Research Unit, EATEN, Copenhagen University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7671-4645","authenticated-orcid":false,"given":"Elna Dalsgaard","family":"Ninh","sequence":"additional","affiliation":[{"name":"The Dietitians and Nutritional Research Unit, EATEN, Copenhagen University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-8815","authenticated-orcid":false,"given":"Anne Wilkens","family":"Knudsen","sequence":"additional","affiliation":[{"name":"The Dietitians and Nutritional Research Unit, EATEN, Copenhagen University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-025X","authenticated-orcid":false,"given":"Tina","family":"Munk","sequence":"additional","affiliation":[{"name":"The Dietitians and Nutritional Research Unit, EATEN, Copenhagen University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-0167","authenticated-orcid":false,"given":"Anne Marie","family":"Beck","sequence":"additional","affiliation":[{"name":"The Dietitians and Nutritional Research Unit, EATEN, Copenhagen University Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Sundhedsv\u00e6senets Kvalitetsinstitut. Dansk Tv\u00e6rfagligt Register for Hoften\u00e6re L\u00e5rbensbrud. 2025. Available from: https:\/\/www.sundk.dk"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16071069"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.OA.18.00045"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaf358"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.05.024"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07088-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050555"},{"key":"e_1_3_3_9_2","article-title":"Effect of oral nutritional supplementation on outcomes in older adults with hip fractures and factors influencing compliance: a systematic review and meta-analysis of randomized controlled trials","volume":"35","author":"Chen B","year":"2023","unstructured":"Chen B, Clement N, Duckworth A. Effect of oral nutritional supplementation on outcomes in older adults with hip fractures and factors influencing compliance: a systematic review and meta-analysis of randomized controlled trials. Aging Clin Exp Res 2023; 35: S243.","journal-title":"Aging Clin Exp Res"},{"key":"e_1_3_3_10_2","article-title":"CONSORT 2010 Statement: extension to randomised pilot and feasibility trials","volume":"355","author":"Eldridge SM","year":"2016","unstructured":"Eldridge SM, Chan CL, Campbell MJ, et al. CONSORT 2010 Statement: extension to randomised pilot and feasibility trials. Br Med J 2016; 355: i5239.","journal-title":"Br Med J"},{"key":"e_1_3_3_11_2","unstructured":"Sundhedsstyrelsen. Underern\u00e6ring. 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