{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:18:10Z","timestamp":1789143490340,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-\u03b1. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-\u03b1, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (\u03b2 = 0.376, p = 0.002), severe pain intensity (\u03b2 = 0.349, p = 0.004), and impaired performance status (\u03b2 = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.<\/jats:p>","DOI":"10.1177\/0269216311406991","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T20:57:15Z","timestamp":1312232235000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["The relationship between interleukin-6, tumor necrosis factor-\u03b1, and fatigue in terminally ill cancer patients"],"prefix":"10.1177","volume":"26","author":[{"given":"Sang Mi","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Korea University Guro Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Seon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, 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