{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:23:43Z","timestamp":1778729023146,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Limited information is available on the symptomatic complications that occur in the last days of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We documented the frequency, clinical course, and survival for 25 symptomatic complications among patients admitted to acute palliative care units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective longitudinal observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Their attending physician completed a daily structured assessment of symptomatic complications from admission to discharge or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/participants:<\/jats:title>\n                    <jats:p>We enrolled consecutive advanced cancer patients admitted to acute palliative care units at MD Anderson Cancer Center, USA, and Barretos Cancer Hospital, Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 352 patients were enrolled (MD Anderson Cancer Center\u2009=\u2009151, Barretos Cancer Hospital\u2009=\u2009201). Delirium, pneumonia, and bowel obstruction were the most common complications, occurring in 43%, 20%, and 16% of patients on admission, and 70%, 46%, and 35% during the entire acute palliative care unit stay, respectively. Symptomatic improvement for delirium (36\/246, 15%), pneumonia (52\/161, 32%), and bowel obstruction (41\/124, 33%) was low. Survival analysis revealed that delirium ( p\u2009&lt;\u20090.001), pneumonia ( p\u2009=\u20090.003), peritonitis ( p\u2009=\u20090.03), metabolic acidosis ( p\u2009&lt;\u20090.001), and upper gastrointestinal bleed ( p\u2009=\u20090.03) were associated with worse survival. Greater number of symptomatic complications on admission was also associated with poorer survival ( p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Symptomatic complications were common in cancer patients admitted to acute palliative care units, often do not resolve completely, and were associated with a poor prognosis despite active medical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269216315583031","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T22:22:11Z","timestamp":1429222931000},"page":"826-833","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Acute symptomatic complications among patients with advanced cancer admitted to acute palliative care units: A prospective observational study"],"prefix":"10.1177","volume":"29","author":[{"given":"David","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Salete","family":"de Angelis Nascimento","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna S","family":"Zhukovsky","sequence":"additional","affiliation":[{"name":"Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Eduardo","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everaldo Donizeti","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heloisa Helena","family":"Scapulatempo","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rony","family":"Dev","sequence":"additional","affiliation":[{"name":"Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Souza","family":"Crovador","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Barretos Cancer Hospital, Barretos, 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