{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:10:25Z","timestamp":1787155825811,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/settings:<\/jats:title>\n                    <jats:p>Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue ( s\u2009=\u20090.49), and physical and functional well-being ( s\u2009=\u20090.44 and s\u2009=\u20090.41, respectively, p\u2009&lt;\u20090.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D ( p\u2009=\u20090.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The 90% frequency of advanced cancer patients with vitamin D deficiency, together with the positive correlation of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient\u2019s quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269216315601954","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T22:29:05Z","timestamp":1440714545000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Vitamin D deficiency and its association with fatigue and quality of life in advanced cancer patients under palliative care: A cross-sectional study"],"prefix":"10.1177","volume":"30","author":[{"given":"Montserrat","family":"Mart\u00ednez-Alonso","sequence":"first","affiliation":[{"name":"Unit of Biostatistics and Methodological Support, IRBLLEIDA, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Dusso","sequence":"additional","affiliation":[{"name":"Division of Experimental Nephrology, IRBLLEIDA, Lleida, Spain"},{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Ariza","sequence":"additional","affiliation":[{"name":"Rehabilitation Unit, Hospital Universitari Arnau de Vilanova de Lleida, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nabal","sequence":"additional","affiliation":[{"name":"Palliative Care Supportive Team, Hospital Universitari Arnau de Vilanova de Lleida, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"bibr1-0269216315601954","volume-title":"Dietary reference intakes for calcium and vitamin D","author":"Institute of Medicine Food and Nutrition Board","year":"2010"},{"key":"bibr2-0269216315601954","volume-title":"Effectiveness and safety of vitamin D","author":"Cranney C","year":"2007"},{"key":"bibr3-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr4-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.582S"},{"key":"bibr5-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.01.005"},{"key":"bibr6-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1201\/9781420019322.ch10"},{"key":"bibr7-0269216315601954","first-page":"198","volume-title":"Present knowledge in nutrition","author":"Norman AW","year":"2006","edition":"9"},{"key":"bibr8-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1773"},{"key":"bibr9-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00336.2004"},{"key":"bibr10-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.06.022"},{"key":"bibr11-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(96)00274-6"},{"key":"bibr12-0269216315601954","first-page":"61","volume":"14","author":"Mahoney FI","year":"1965","journal-title":"Md State Med J"},{"key":"bibr13-0269216315601954","first-page":"196","volume-title":"Evaluation of chemotherapeutic agents","author":"Karnofsky DA","year":"1949"},{"key":"bibr14-0269216315601954","doi-asserted-by":"publisher","DOI":"10.1177\/082585979601200102"},{"key":"bibr15-0269216315601954","unstructured":"R Core Team. 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