{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:33Z","timestamp":1790885553131,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GY1712"],"award-info":[{"award-number":["01GY1712"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sedatives are frequently used towards the end of life. However, there is scarce information when their use is labelled as \u2018palliative sedation\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To assess the use and labelling of \u2018continuous administration of sedatives within the last 7\u2009days of life\u2019, based on objective operational criteria, on a palliative care unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study, using medical records. Explorative statistical analysis (SPSS 23).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/participants:<\/jats:title>\n                    <jats:p>Patients who died on a palliative care unit from August 2014 to July 2015. Sedatives recorded were benzodiazepines, levomepromazine, haloperidol \u2a7e5\u2009mg\/day and propofol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 192 patients, 149 (78%) patients received continuous sedatives within the last week of life. The prevalence of delirium\/agitation was significantly higher in patients with continuous sedatives compared to those without continuous sedatives at admission to the unit (35% vs 16%, p\u2009=\u20090.02) and on the day before death (58% vs 40%, p\u2009=\u20090.04). The term \u2018(palliative) sedation\u2019 was used in the records for 22 of 149 (15%) patients with continuous sedatives. These patients had significantly higher total daily midazolam doses 2\u2009days before death (median (range), 15.0 (6.0\u2013185.0)\u2009mg vs 11.5 (1.0\u201370.0)\u2009mg, p\u2009=\u20090.04) and on the day of death (median (range), 19.5 (7.5\u2013240.0)\u2009mg vs 12.5 (2.0\u201365.0)\u2009mg, p\u2009=\u20090.01). The dose range was large in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prevalence of delirium\/agitation was associated with the administration of continuous sedatives. There was no consistent pattern regarding labelling the use of continuous sedatives as \u2018(palliative) sedation\u2019. Multicentre mixed-methods research is needed for a better characterization of sedation practices in palliative care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269216318764095","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T05:48:09Z","timestamp":1521524889000},"page":"1189-1197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["\u2018Palliative sedation\u2019? 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