{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:09:26Z","timestamp":1777918166168,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Aprepitant, a substance P neurokinin-1 receptor antagonist, is licenced for the prevention of acute and delayed nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 33\u2009year-old male with metastatic gastro-oesophageal cancer had multiple admissions for refractory nausea and vomiting following insertion of an oesophageal stent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Action:<\/jats:title>\n                    <jats:p>Mechanical issues with the stent, stent removal and central causes were excluded. Multiple anti-emetic agents were trialled in combination and with varying routes of administration without significant symptomatic improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Formulation:<\/jats:title>\n                    <jats:p>A trial of aprepitant was proposed as an off-licence therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome:<\/jats:title>\n                    <jats:p>One hundred sixty-five milligrammes of aprepitant was given orally every 3\u2009days and then up titrated to once daily with significant symptomatic improvement enabling the patient to tolerate an oral diet. The patient remained stable at 12\u2009weeks and has been accepted into two clinical trials for potential further cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lessons:<\/jats:title>\n                    <jats:p>Aprepitant can be effective in refractory nausea and vomiting outside of emetogenic chemotherapy and safely used as a chronic treatment. The prevalence of refractory nausea and vomiting as a rare adverse outcome post-oesophageal stent insertion should be studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>What now?<\/jats:title>\n                    <jats:p>Further research of neurokinin-1 inhibitors for indications other than chemotherapy-induced nausea and vomiting is indicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163211065276","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:10:20Z","timestamp":1640131820000},"page":"395-398","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of long term aprepitant as a treatment for refractory nausea following oesophageal stent insertion \u2013 a case report"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-0852","authenticated-orcid":false,"given":"Richard","family":"Shoulder","sequence":"first","affiliation":[{"name":"Central Coast Local Health District, Gosford Hospital, Gosford, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Taylor","sequence":"additional","affiliation":[{"name":"Hunter New England Local Health District, Calvary Mater Newcastle, Waratah, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Stiel","sequence":"additional","affiliation":[{"name":"Palliative Care, Central Coast Local Health District, Gosford Hospital, Gosford, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"bibr1-02692163211065276","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0231-4"},{"key":"bibr2-02692163211065276","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R484"},{"key":"bibr3-02692163211065276","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.50"},{"key":"bibr4-02692163211065276","doi-asserted-by":"publisher","DOI":"10.1177\/0269216314530180"},{"key":"bibr5-02692163211065276","unstructured":"Ibrahim MA, Preuss CV. Antiemetic neurokinin-1 receptor blockers. Treasure Island, FL: StatPearls Publishing; 2021. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470394\/ (accessed 17 February 2021)."},{"key":"bibr6-02692163211065276","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901213400304"},{"key":"bibr7-02692163211065276","unstructured":"Therapeutic Goods Administration, Australian Government Department of Health. Product information for AusPAR Emend Aprepitant Merck, Sharp & Dohme. Therapeutic Goods Administration. Report PM-2011-00237-3-4 Final. https:\/\/www.tga.gov.au\/file\/724\/download (accessed 5 December 2021)."},{"issue":"8","key":"bibr8-02692163211065276","first-page":"526","volume":"8","author":"Hindy P","year":"2012","journal-title":"Gastroenterol Hepatol"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163211065276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02692163211065276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163211065276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:32:38Z","timestamp":1777660358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02692163211065276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,21]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/02692163211065276"],"URL":"https:\/\/doi.org\/10.1177\/02692163211065276","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,21]]}}}