{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T01:18:12Z","timestamp":1778375892057,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1065571"],"award-info":[{"award-number":["APP1065571"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic breathlessness adversely impacts people with chronic obstructive pulmonary disease and their caregivers (family and friends), who may, in turn, experience significant burden due to their caregiving role. Sustained-release morphine may reduce chronic breathlessness in some patients, which may have an impact on caregivers\u2019 perceived burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To explore the impact on caregiver burden of active treatment of people with chronic breathlessness (modified Medical Research Council (mMRC)\u2009\u2a7e\u20093) and chronic obstructive pulmonary disease (COPD) with regular, low-dose, sustained-release morphine within a multi-site, double-blind, randomised, placebo-controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Exploratory analysis of self-reported caregiver burden at baseline and end of week 3 in a randomised, double-blind, placebo-controlled study. Caregiver measures included: demographics and perceived burden (Zarit Burden Interview 12-item short-form questionnaire). Patient measures included: worst breathlessness and FitBit\n                      <jats:sup>R<\/jats:sup>\n                      -measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/participants:<\/jats:title>\n                    <jats:p>All consenting caregivers of trial patient participants in a multi-site study recruiting from palliative care and respiratory services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Caregivers ( n\u2009=\u200949; 59% women; median age 68\u2009years [IQR 50\u201375]) reported median baseline caregiver burden 12 [IQR 5\u201317], with 53% reporting high burden (\u2a7e13). Eighty-four percent of caregivers reported no change in burden. In people whose worst breathlessness improved, caregiver burden moved in the same direction, though the correlation was not significant ( r\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u20090.25, p\u2009=\u20090.17). Conversely, caregiver burden worsened as patients\u2019 minutes lightly active increased, with the correlation being significant ( r\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u20090.56, p\u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Caregivers reported high levels of caregiver burden, but patients\u2019 response to treatment in terms of their symptom and function may influence change in caregiver burden over a three-week period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163231211227","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:52:20Z","timestamp":1700265140000},"page":"156-162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of regular, low-dose, sustained-release morphine for chronic breathlessness on caregiver burden: An exploratory analysis of the BEAMS trial"],"prefix":"10.1177","volume":"38","author":[{"given":"Slavica","family":"Kochovska","sequence":"first","affiliation":[{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungwon","family":"Chang","sequence":"additional","affiliation":[{"name":"IMPACCT, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Luckett","sequence":"additional","affiliation":[{"name":"IMPACCT, Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-5841","authenticated-orcid":false,"given":"Jessica","family":"Roydhouse","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Clinical Sciences, Respiratory Medicine, Allergology and Palliative Medicine, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-1250","authenticated-orcid":false,"given":"David C","family":"Currow","sequence":"additional","affiliation":[{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"bibr1-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02277-2016"},{"key":"bibr2-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01159-2017"},{"key":"bibr3-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.09.021"},{"key":"bibr4-02692163231211227","unstructured":"The University of Manchester\/University of Cambridge. The Carer Support Needs Assessment Tool Intervention (CSNAT-I). https:\/\/csnat.org\/ (2022, (accessed 12 September 2023)."},{"key":"bibr5-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1177\/0269216313488812"},{"key":"bibr6-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000281"},{"key":"bibr7-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.581"},{"key":"bibr8-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213681"},{"key":"bibr9-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.20206"},{"key":"bibr10-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3134"},{"key":"bibr11-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-020-00572-7"},{"key":"bibr12-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177081"},{"key":"bibr13-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018100"},{"key":"bibr14-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1725"},{"key":"bibr15-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/2312508X.10011315"},{"key":"bibr16-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/41.5.652"},{"key":"bibr17-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/20.6.649"},{"key":"bibr18-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642018dn13-010015"},{"key":"bibr19-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11099"},{"key":"bibr20-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01484-2022"},{"key":"bibr21-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.014"},{"key":"bibr22-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951503030499"},{"key":"bibr23-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01477-2017"},{"key":"bibr24-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04613-2020"},{"key":"bibr25-02692163231211227","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02471-2018"}],"container-title":["Palliative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163231211227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02692163231211227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02692163231211227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:35:43Z","timestamp":1777660543000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02692163231211227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/02692163231211227"],"URL":"https:\/\/doi.org\/10.1177\/02692163231211227","relation":{},"ISSN":["0269-2163","1477-030X"],"issn-type":[{"value":"0269-2163","type":"print"},{"value":"1477-030X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,17]]}}}