{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:10:00Z","timestamp":1789049400215,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004095","name":"Kyowa Kirin","doi-asserted-by":"publisher","award":["R18591-1"],"award-info":[{"award-number":["R18591-1"]}],"id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background:<\/jats:title>\n Constipation is common in people with advanced cancer and is associated with significant morbidity and health economic burden, but it is often sub-optimally managed. Despite international consensus diagnostic criteria for functional and opioid-induced constipation (Rome IV diagnostic criteria), the term \u2018constipation\u2019 means different things to different people, impacting assessment, diagnosis and management.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To investigate the association between persons with advanced cancer self-reporting of constipation, response to the Rome IV diagnostic criteria statements for opioid-induced constipation and differences according to personal demographics.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Multicentre prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Setting\/participants:<\/jats:title>\n Twenty-four community, hospice and hospital research sites in 10 European countries recruited 1200 adults with cancer taking opioids for cancer\/cancer-treatment related pain.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In response to the simple question\n \u2018Are you constipated?\u2019<\/jats:italic>\n , 549 (45.5%) participants replied \u2018yes\u2019, 588 (49%) replied \u2018no\u2019 and 59 (5%) were \u2018unsure\u2019, but 713 (59.5%) participants met the Rome IV diagnostic criteria. Only 439 (61.5%) participants that met these criteria answered the simple question positively, whilst 230 (39%) answered negatively, although there was a statistically significant association between responses to the simple question and the criteria (\u03c7\n 2<\/jats:sup>\n (1,\n N<\/jats:italic>\n \u2009=\u20091136)\u2009=\u2009149.945,\n p<\/jats:italic>\n \u2009=\u20090.00001). There were certain significant differences in self-reporting according to age and country of origin.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n There is disparity between patients\u2019 self-reporting of constipation and the Rome IV diagnostic criteria. People with advanced cancer, especially those receiving opioid analgesics, need to be regularly assessed for constipation, but the use of a single question (\n \u2018Are you constipated?\u2019<\/jats:italic>\n ) is inadequate.\n <\/jats:p>\n \n Registry: European Study of Opioid Induced Constipation (E-StOIC), NCT05149833,\n https:\/\/clinicaltrials.gov\/study\/NCT05149833<\/jats:ext-link>\n , 08\/12\/2021.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/02692163251325711","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:33:41Z","timestamp":1741768421000},"page":"553-562","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["\u2018Constipation\u2019: One word, many meanings amongst persons with cancer: An observational study"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-4799","authenticated-orcid":false,"given":"Andrew","family":"Davies","sequence":"first","affiliation":[{"name":"School of Medicine, Trinity College Dublin, Dublin, Ireland"},{"name":"School of Medicine, University College Dublin, Dublin, Ireland"},{"name":"Academic Department of Palliative Medicine, Our Lady\u2019s Hospice & Care Services, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah","family":"Fagan","sequence":"additional","affiliation":[{"name":"Academic Department of Palliative Medicine, Our Lady\u2019s Hospice & Care Services, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-6581","authenticated-orcid":false,"given":"Jenny","family":"Power","sequence":"additional","affiliation":[{"name":"School of Medicine, University College Dublin, Dublin, Ireland"},{"name":"Academic Department of Palliative Medicine, Our Lady\u2019s Hospice & Care Services, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-6662","authenticated-orcid":false,"given":"Amy","family":"Taylor","sequence":"additional","affiliation":[{"name":"School of Medicine, Trinity College Dublin, Dublin, Ireland"},{"name":"Academic Department of Palliative Medicine, Our Lady\u2019s Hospice & Care Services, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05016-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002024"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269216312450358"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2004.10.7.14570"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2017.01.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4366-z"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-1051-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-0994-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269216308096908"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199656097.003.0203"},{"issue":"4","key":"e_1_3_3_12_2","article-title":"Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines","volume":"29","author":"Larkin PJ","year":"2018","unstructured":"Larkin PJ, Cherny NI, La Carpia D, et al Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines. Ann Oncol 2018; 29(Suppl 4): iv111\u2013iv125.","journal-title":"Ann Oncol"},{"key":"e_1_3_3_13_2","first-page":"545","volume-title":"Oxford textboook of palliative medicine","author":"Larkin PJ.","year":"2015","unstructured":"Larkin PJ. Constipation and diarrhoea. In: Cherny NI, Fallon MT, Kaasa S, et al (eds) Oxford textboook of palliative medicine. 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