{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:15:23Z","timestamp":1792541723805,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Palliative Care is concerned with relieving suffering and improving the quality of life of patients and their families. Currently, questions arise about how to provide patients with good end-of-life care. There has been increasing interest in the beneficial effects of using psilocybin-assisted therapy in patients with severe chronic illnesses near the end of their lives and who present symptoms of depression and\/or anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Explore the role of psilocybin-assisted therapy in palliative care, synthesizing evidence from clinical trials and longitudinal studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources:<\/jats:title>\n                    <jats:p>A bibliographic search was performed in April 2024 in B-on, PubMed, Web of Science, and Scopus. Eligible studies included peer-reviewed quantitative research (RCTs, longitudinal, and observational designs) with adult participants in palliative care settings, examining the efficacy and safety of psilocybin-assisted therapy. Reviews, gray literature, and studies outside the scope of palliative care were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 215 articles found, six studies (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200974 participants; age range 22\u201375\u2009years) met the inclusion criteria. Across randomized and open-label trials, psilocybin-assisted therapy produced clinically significant reductions in depression and anxiety, with 57\u201379% of participants achieving\u2009\u2a7e\u200950% symptom reduction on standardized scales (e.g. HAM-D, HAM-A, BDI, STAI). Improvements were sustained for up to 6\u20138\u2009months in most trials, and in one follow-up study, for up to 4.5\u2009years. Reported adverse effects were generally mild and transient, including nausea, vomiting, and temporary increases in blood pressure and heart rate; no serious adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Psilocybin-assisted therapy consistently demonstrated efficacy and safety in the reduction of depressive and anxiety symptoms. However, more studies exploring integrating psilocybin-assisted therapy into existing palliative care healthcare systems are needed. This includes investigating the feasibility, acceptability, and cost-effectiveness of integrating psilocybin-assisted therapy into routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02692163251383335","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:40:11Z","timestamp":1766058011000},"page":"7-20","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Psilocybin-assisted therapy for individuals with palliative care needs: A systematic review of safety and efficacy"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0199-0467","authenticated-orcid":false,"given":"Ana Rita Sousa","family":"Matos","sequence":"first","affiliation":[{"name":"Academic Clinical Center of Tr\u00e1s-os-Montes and Alto Douro (CACTMAD), University of Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"},{"name":"Community-Based Palliative Care Support Team Terra Quente, Mirandela, Portugal"},{"name":"Unidade Sa\u00fade Familiar Tua Sa\u00fade, Mirandela, Northeast Local Health Unit (ULSNE), Mirandela, Portugal"},{"name":"Palliative Medicine Team, Alto Ave Local Health Unit, Guimar\u00e3es, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0331-8897","authenticated-orcid":false,"given":"Ana Catarina","family":"Silva","sequence":"additional","affiliation":[{"name":"Palliative Medicine Team, Alto Ave Local Health Unit, Guimar\u00e3es, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lic\u00ednio","family":"Rego","sequence":"additional","affiliation":[{"name":"Portuguese Oncology Institute of Porto Francisco Gentil, (IPO)-Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-8789","authenticated-orcid":false,"given":"Rui","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Portuguese Oncology Institute of Porto Francisco Gentil, (IPO)-Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8287-1357","authenticated-orcid":false,"given":"Sara","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Academic Clinical Center of Tr\u00e1s-os-Montes and Alto Douro (CACTMAD), University of Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2022.0036"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2016.1278228"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/02698811221092508"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102948"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13670-023-00383-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2011.07.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00171"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10508619.2022.2148062"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2022.100410"},{"key":"e_1_3_3_11_2","first-page":"3","article-title":"Indigenous psilocybin mushroom practices: an annotated bibliography","volume":"8","author":"Spiers N","year":"2024","unstructured":"Spiers N, Labate BC, Ermakova AO, et al. 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